Review on the Synthesis of Pyrazine and Its Derivatives
Pyrazine is a kind of natural product which can be found in plants, animals, insects, marine organisms and microorganisms. The main function of pyrazine in living organisms is used as flavor of the raw foods. Pyrazine and its derivatives were also produced in industries mainly for fragrance, flavo...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universiti Malaysia Sarawak, (UNIMAS)
2017
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/21874/7/Review%20on.pdf http://ir.unimas.my/id/eprint/21874/ http://publisher.unimas.my/ojs/index.php/BJRST/article/view/591 |
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| Summary: | Pyrazine is a kind of natural product which can be found in plants, animals, insects, marine organisms and
microorganisms. The main function of pyrazine in living organisms is used as flavor of the raw foods. Pyrazine
and its derivatives were also produced in industries mainly for fragrance, flavor and pharmaceutical applications.
This review describes the historical development of pyrazine including the discovery and synthesis, to the recent
synthetic approach of pyrazinium. In general, six synthetic approaches namely condensation reaction, ring
closure, metal catalysis, green reaction, Maillard reaction and acid catalyst on N-substitution have been reviewed
in this paper. The first five approaches are mainly aimed for the substitution at 2, 3, 5 and 6 positions in pyrazine
ring, whereas the last approach is specifically for 1 and 4 positions in pyrazine. |
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