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Synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length

A series of (E)-1-(4-alkyloxyphenyl)-3-(hydroxyphenyl)-prop-2-en-1-one have been successfully synthesised via Claisen–Schmidt condensation. The synthesised chalcone derivatives consisted of hydroxyl groups at either ortho, meta or para position and differed in the length of the alkyl groups, CnH...

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Main Authors: Zainab, Ngaini, Siti M., Haris Fadzillah, Hasnain, Hussain
Format: Article
Language:English
Published: Taylor & Francis 2012
Subjects:
Q Science (General)
Online Access:http://ir.unimas.my/id/eprint/15581/1/zainab11.pdf
http://ir.unimas.my/id/eprint/15581/
http://dx.doi.org/10.1080/14786419.2010.502896
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spelling my.unimas.ir.155812021-04-24T22:09:31Z http://ir.unimas.my/id/eprint/15581/ Synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length Zainab, Ngaini Siti M., Haris Fadzillah Hasnain, Hussain Q Science (General) A series of (E)-1-(4-alkyloxyphenyl)-3-(hydroxyphenyl)-prop-2-en-1-one have been successfully synthesised via Claisen–Schmidt condensation. The synthesised chalcone derivatives consisted of hydroxyl groups at either ortho, meta or para position and differed in the length of the alkyl groups, CnH2nþ1, where n¼6, 10, 12 and 14. The structures of all compounds were defined by elemental analysis, IR, 1H- and 13C-NMR. The antimicrobial studies were carried out against wild-type Escherichia coli American Type Culture Collection 8739 to evaluate the effect of the hydroxyl and the alkyl groups of the synthesised chalcones. All the synthesised compounds have shown significant antimicrobial activities. The optimum inhibition was dependent on the position of the hydroxyl group as well as the length of the alkyl chains. Taylor & Francis 2012 Article PeerReviewed text en http://ir.unimas.my/id/eprint/15581/1/zainab11.pdf Zainab, Ngaini and Siti M., Haris Fadzillah and Hasnain, Hussain (2012) Synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length. Natural Product Research, 26 (10). pp. 892-902. ISSN 1478-6427 http://dx.doi.org/10.1080/14786419.2010.502896 DOI: 10.1080/14786419.2010.502896
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic Q Science (General)
spellingShingle Q Science (General)
Zainab, Ngaini
Siti M., Haris Fadzillah
Hasnain, Hussain
Synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length
description A series of (E)-1-(4-alkyloxyphenyl)-3-(hydroxyphenyl)-prop-2-en-1-one have been successfully synthesised via Claisen–Schmidt condensation. The synthesised chalcone derivatives consisted of hydroxyl groups at either ortho, meta or para position and differed in the length of the alkyl groups, CnH2nþ1, where n¼6, 10, 12 and 14. The structures of all compounds were defined by elemental analysis, IR, 1H- and 13C-NMR. The antimicrobial studies were carried out against wild-type Escherichia coli American Type Culture Collection 8739 to evaluate the effect of the hydroxyl and the alkyl groups of the synthesised chalcones. All the synthesised compounds have shown significant antimicrobial activities. The optimum inhibition was dependent on the position of the hydroxyl group as well as the length of the alkyl chains.
format Article
author Zainab, Ngaini
Siti M., Haris Fadzillah
Hasnain, Hussain
author_facet Zainab, Ngaini
Siti M., Haris Fadzillah
Hasnain, Hussain
author_sort Zainab, Ngaini
title Synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length
title_short Synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length
title_full Synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length
title_fullStr Synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length
title_full_unstemmed Synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length
title_sort synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length
publisher Taylor & Francis
publishDate 2012
url http://ir.unimas.my/id/eprint/15581/1/zainab11.pdf
http://ir.unimas.my/id/eprint/15581/
http://dx.doi.org/10.1080/14786419.2010.502896
_version_ 1698700767604506624
score 13.211869

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