Synthesis and antimicrobial studies of hydroxylated chalcone derivatives with variable chain length
A series of (E)-1-(4-alkyloxyphenyl)-3-(hydroxyphenyl)-prop-2-en-1-one have been successfully synthesised via Claisen–Schmidt condensation. The synthesised chalcone derivatives consisted of hydroxyl groups at either ortho, meta or para position and differed in the length of the alkyl groups, CnH...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis
2012
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/15581/1/zainab11.pdf http://ir.unimas.my/id/eprint/15581/ http://dx.doi.org/10.1080/14786419.2010.502896 |
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| Summary: | A series of (E)-1-(4-alkyloxyphenyl)-3-(hydroxyphenyl)-prop-2-en-1-one
have been successfully synthesised via Claisen–Schmidt condensation.
The synthesised chalcone derivatives consisted of hydroxyl groups at either
ortho, meta or para position and differed in the length of the alkyl groups,
CnH2nþ1, where n¼6, 10, 12 and 14. The structures of all compounds were
defined by elemental analysis, IR, 1H- and 13C-NMR. The antimicrobial
studies were carried out against wild-type Escherichia coli American Type
Culture Collection 8739 to evaluate the effect of the hydroxyl and the alkyl
groups of the synthesised chalcones. All the synthesised compounds have
shown significant antimicrobial activities. The optimum inhibition was
dependent on the position of the hydroxyl group as well as the length of
the alkyl chains. |
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