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Precision Medicine for Sepsis Management in Low- and Middle-Income Countries—Melioidosis as a Model?

Advances in translational critical care have revealed limitations in the current clinical management of critical illness, which is syndrome based. Studies evaluating the host response using immunoassays, multi-omics platforms, and bioinformatics analysis have identified heterogenous subgroups (subph...

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Main Authors: Wen, Yeo Tsin, Allen C., Cheng, Yuwana, Podin
Format: Article
Language:English
Published: American Thoracic Society 2024
Subjects:
RA0421 Public health. Hygiene. Preventive Medicine
Online Access:http://ir.unimas.my/id/eprint/46917/1/Precision%20Medicine.pdf
http://ir.unimas.my/id/eprint/46917/
https://www.atsjournals.org/doi/10.1164/rccm.202311-2056ED?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
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id my.unimas.ir-46917
record_format eprints
spelling my.unimas.ir-469172024-12-16T07:29:09Z http://ir.unimas.my/id/eprint/46917/ Precision Medicine for Sepsis Management in Low- and Middle-Income Countries—Melioidosis as a Model? Wen, Yeo Tsin Allen C., Cheng Yuwana, Podin RA0421 Public health. Hygiene. Preventive Medicine Advances in translational critical care have revealed limitations in the current clinical management of critical illness, which is syndrome based. Studies evaluating the host response using immunoassays, multi-omics platforms, and bioinformatics analysis have identified heterogenous subgroups (subphenotypes) as well as distinct pathogenic features (endotypes) among patients diagnosed with sepsis. This has led to the aim of utilizing a precision medicine approach, where targeted therapeutic management is based on the utilization of assays to identify subphenotypes or clinical correlates of endotypes. This approach has been used in oncology with significant improvement in outcomes by targeting the underlying biological mechanism in individual patients. American Thoracic Society 2024-02-01 Article PeerReviewed text en http://ir.unimas.my/id/eprint/46917/1/Precision%20Medicine.pdf Wen, Yeo Tsin and Allen C., Cheng and Yuwana, Podin (2024) Precision Medicine for Sepsis Management in Low- and Middle-Income Countries—Melioidosis as a Model? American Journal of Respiratory and Critical Care Medicine, 209 (3). pp. 237-238. ISSN 1073-449X https://www.atsjournals.org/doi/10.1164/rccm.202311-2056ED?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed DOI 10.1164/rccm.202311-2056ED
institution Universiti Malaysia Sarawak
building Centre for Academic Information Services (CAIS)
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sarawak
content_source UNIMAS Institutional Repository
url_provider http://ir.unimas.my/
language English
topic RA0421 Public health. Hygiene. Preventive Medicine
spellingShingle RA0421 Public health. Hygiene. Preventive Medicine
Wen, Yeo Tsin
Allen C., Cheng
Yuwana, Podin
Precision Medicine for Sepsis Management in Low- and Middle-Income Countries—Melioidosis as a Model?
description Advances in translational critical care have revealed limitations in the current clinical management of critical illness, which is syndrome based. Studies evaluating the host response using immunoassays, multi-omics platforms, and bioinformatics analysis have identified heterogenous subgroups (subphenotypes) as well as distinct pathogenic features (endotypes) among patients diagnosed with sepsis. This has led to the aim of utilizing a precision medicine approach, where targeted therapeutic management is based on the utilization of assays to identify subphenotypes or clinical correlates of endotypes. This approach has been used in oncology with significant improvement in outcomes by targeting the underlying biological mechanism in individual patients.
format Article
author Wen, Yeo Tsin
Allen C., Cheng
Yuwana, Podin
author_facet Wen, Yeo Tsin
Allen C., Cheng
Yuwana, Podin
author_sort Wen, Yeo Tsin
title Precision Medicine for Sepsis Management in Low- and Middle-Income Countries—Melioidosis as a Model?
title_short Precision Medicine for Sepsis Management in Low- and Middle-Income Countries—Melioidosis as a Model?
title_full Precision Medicine for Sepsis Management in Low- and Middle-Income Countries—Melioidosis as a Model?
title_fullStr Precision Medicine for Sepsis Management in Low- and Middle-Income Countries—Melioidosis as a Model?
title_full_unstemmed Precision Medicine for Sepsis Management in Low- and Middle-Income Countries—Melioidosis as a Model?
title_sort precision medicine for sepsis management in low- and middle-income countries—melioidosis as a model?
publisher American Thoracic Society
publishDate 2024
url http://ir.unimas.my/id/eprint/46917/1/Precision%20Medicine.pdf
http://ir.unimas.my/id/eprint/46917/
https://www.atsjournals.org/doi/10.1164/rccm.202311-2056ED?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
_version_ 1818839394143961088
score 13.223943

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