Precision Medicine for Sepsis Management in Low- and Middle-Income Countries—Melioidosis as a Model?
Advances in translational critical care have revealed limitations in the current clinical management of critical illness, which is syndrome based. Studies evaluating the host response using immunoassays, multi-omics platforms, and bioinformatics analysis have identified heterogenous subgroups (subph...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Thoracic Society
2024
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/46917/1/Precision%20Medicine.pdf http://ir.unimas.my/id/eprint/46917/ https://www.atsjournals.org/doi/10.1164/rccm.202311-2056ED?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed |
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| Summary: | Advances in translational critical care have revealed limitations in the current clinical management of critical illness, which is syndrome based. Studies evaluating the host response using immunoassays, multi-omics platforms, and bioinformatics analysis have identified heterogenous subgroups (subphenotypes) as well as distinct pathogenic features (endotypes) among patients diagnosed with sepsis. This has led to the aim of utilizing a precision medicine approach, where targeted therapeutic management is based on the utilization of assays to identify subphenotypes or clinical correlates of endotypes. This approach has been used in oncology with significant improvement in outcomes by targeting the underlying biological mechanism in individual patients. |
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