Characterization of bioactive compounds of selected bacteria from the Tropics and Antarctic
Antibiotic resistance in bacteria can arise through two primary mechanisms: vertical gene transfer, where resistant traits are inherited by offspring, and horizontal gene transfer (HGT), where genetic material is exchanged between different bacterial species through mobile genetic elements such as p...
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| Format: | Thesis |
| Language: | English English |
| Published: |
2013
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| Online Access: | https://eprints.ums.edu.my/id/eprint/42823/1/24%20PAGES.pdf https://eprints.ums.edu.my/id/eprint/42823/2/FULLTEXT.pdf https://eprints.ums.edu.my/id/eprint/42823/ |
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| Summary: | Antibiotic resistance in bacteria can arise through two primary mechanisms: vertical gene transfer, where resistant traits are inherited by offspring, and horizontal gene transfer (HGT), where genetic material is exchanged between different bacterial species through mobile genetic elements such as plasmids and transposons. While vertical gene transfer plays a role in resistance inheritance, HGT has been shown to be a more rapid and widespread process. Recent studies by Smillie et al. (2011) indicate that HGT of antibiotic resistance genes occurs at a significantly higher rate compared to other genetic traits, with most exchanges occurring within the same ecological environments. This ecological-driven gene transfer emphasizes the importance of environmental factors in the spread of resistance. These findings highlight the urgency of developing new classes of antibiotics to combat the rapid and escalating spread of resistance in pathogenic bacteria. |
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