Impairment of IgG Fc functions promotes tumor progression and suppresses NK cell antitumor actions
Natural killer (NK) cells mediate antibody dependent cytotoxic killing of cancer cells via cross-linking FcγR on NK cells with IgG-Fc. Studies have shown that the single-hinge cleaved IgGs (scIgGs) have dysfunctional Fc and failed engagement with FcγRs on immune cells. However, little is known about...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Springer Nature
2022
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| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/34647/2/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/34647/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/34647/ https://www.nature.com/articles/s42003-022-03931-7.pdf https://doi.org/10.1038/s42003-022-03931-7 |
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