Synthesis of new 1,2-disubstituted benzimidazole analogs as potent inhibitors of b-Glucuronidase and in silico study
New benzimidazole analogues (1–18) were synthesized and characterized through differ- ent spectroscopic techniques such as 1H NMR, 13C NMR and HREI-MS. All analogues were screened for b-glucuronidase inhibitory potential. All analogues showed varied degree of inhibitory potentials with IC50 values r...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Elsevier B.V.
2022
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| Subjects: | |
| Online Access: | https://eprints.ums.edu.my/id/eprint/32642/1/Synthesis%20of%20new%201%2C2-disubstituted%20benzimidazole%20analogs%20as%20potent%20inhibitors%20of%20b-Glucuronidase%20and%20in%20silico%20study.pdf https://eprints.ums.edu.my/id/eprint/32642/2/Synthesis%20of%20new%201%2C2-disubstituted%20benzimidazole%20analogs%20as%20potent%20inhibitors%20of%20b-Glucuronidase%20and%20in%20silico%20study1.pdf https://eprints.ums.edu.my/id/eprint/32642/ https://www.sciencedirect.com/science/article/pii/S1878535221005207 https://doi.org/10.1016/j.arabjc.2021.103505 |
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