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Synthesis of chromen-4-one-oxadiazole substituted analogs as potent β-glucuronidase inhibitors

Chromen-4-one substituted oxadiazole analogs 1–19 have been synthesized, characterized and evaluated for β-glucuronidase inhibition. All analogs exhibited a variable degree of β-glucuronidase inhibitory activity with IC50 values ranging in between 0.8 ± 0.1–42.3 ± 0.8 µM when compared with the st...

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Bibliographic Details
Main Authors: Taha, Muhammad, Rahim, Faizal, Ali, Muhammad, Khan, Muhammad Naseem, Alqahtani, Mohammed A., Bamarouf, Yasser A., Gollapalli, Mohammed, Farooq, Rai Khalid, Ali Shah, Syed Adnan, Ahmed, Qamar Uddin, Zakaria, Zainul Amiruddin
Format: Article
Language:English
English
English
Published: MDPI 2019
Subjects:
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/72570/1/72570%20Synthesis%20of%20chromen-4-one-oxadiazole.pdf
http://irep.iium.edu.my/72570/2/72570%20Synthesis%20of%20chromen-4-one-oxadiazole%20SCOPUS.pdf
http://irep.iium.edu.my/72570/13/72570_Synthesis%20of%20Chromen-4-One-Oxadiazole%20Substituted%20Analogs%20as%20Potent%20-Glucuronidase%20Inhibitors_wos.pdf
http://irep.iium.edu.my/72570/
https://www.mdpi.com/1420-3049/24/8/1528
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http://irep.iium.edu.my/72570/1/72570%20Synthesis%20of%20chromen-4-one-oxadiazole.pdf
http://irep.iium.edu.my/72570/2/72570%20Synthesis%20of%20chromen-4-one-oxadiazole%20SCOPUS.pdf
http://irep.iium.edu.my/72570/13/72570_Synthesis%20of%20Chromen-4-One-Oxadiazole%20Substituted%20Analogs%20as%20Potent%20-Glucuronidase%20Inhibitors_wos.pdf
http://irep.iium.edu.my/72570/
https://www.mdpi.com/1420-3049/24/8/1528

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