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Gliosarcoma of a brain: a challenging diagnosis

Gliosarcoma is a rare primary malignant tumour of the central nervous system. A 28-year-old radiographer without a history of neurological disorder, malignancy or trauma presented with unprovoked seizures. He was symptom-free for 3 years but developed relapsed. Computed tomography of the brain was c...

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Main Authors: Nornazirah Azizan, Nor Haizura Ab Rani, Ahmad Toha Samsudin, Fadhli Mustaffa, Firdaus Hayati
Format: Article
Language:English
English
Published: Universiti Malaysia Sabah 2020
Subjects:
R Medicine (General)
Online Access:https://eprints.ums.edu.my/id/eprint/27027/1/Gliosarcoma%20of%20a%20Brain%2C%20A%20Challenging%20Diagnosis-Abstract.pdf
https://eprints.ums.edu.my/id/eprint/27027/2/Gliosarcoma%20of%20a%20Brain%2C%20A%20Challenging%20Diagnosis.pdf
https://eprints.ums.edu.my/id/eprint/27027/
https://jurcon.ums.edu.my/ojums/index.php/bjms/article/view/2060/1744
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spelling my.ums.eprints.270272021-05-27T02:58:58Z https://eprints.ums.edu.my/id/eprint/27027/ Gliosarcoma of a brain: a challenging diagnosis Nornazirah Azizan Nor Haizura Ab Rani Ahmad Toha Samsudin Fadhli Mustaffa Firdaus Hayati R Medicine (General) Gliosarcoma is a rare primary malignant tumour of the central nervous system. A 28-year-old radiographer without a history of neurological disorder, malignancy or trauma presented with unprovoked seizures. He was symptom-free for 3 years but developed relapsed. Computed tomography of the brain was consistent with anaplastic convexity meningioma which was identical via intraoperative findings. However, the final histology revealed gliosarcoma of the brain. He recovered well postoperatively without any neurological deficit and had completed adjuvant chemoradiotherapy. He was asymptomatic during follow up with no tumour recurrence. Gliosarcoma with predominant sarcomatous component mimicking a meningioma has prolonged survival as compared to a case with predominant glioblastoma component. Hence, the discordance between clinical, radiological, intraoperative and histopathological findings is a challenge in establishing a diagnosis of gliosarcoma. Universiti Malaysia Sabah 2020-09 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/27027/1/Gliosarcoma%20of%20a%20Brain%2C%20A%20Challenging%20Diagnosis-Abstract.pdf text en https://eprints.ums.edu.my/id/eprint/27027/2/Gliosarcoma%20of%20a%20Brain%2C%20A%20Challenging%20Diagnosis.pdf Nornazirah Azizan and Nor Haizura Ab Rani and Ahmad Toha Samsudin and Fadhli Mustaffa and Firdaus Hayati (2020) Gliosarcoma of a brain: a challenging diagnosis. Borneo Journal of Medical Sciences, 14 (3). pp. 39-44. https://jurcon.ums.edu.my/ojums/index.php/bjms/article/view/2060/1744
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
English
topic R Medicine (General)
spellingShingle R Medicine (General)
Nornazirah Azizan
Nor Haizura Ab Rani
Ahmad Toha Samsudin
Fadhli Mustaffa
Firdaus Hayati
Gliosarcoma of a brain: a challenging diagnosis
description Gliosarcoma is a rare primary malignant tumour of the central nervous system. A 28-year-old radiographer without a history of neurological disorder, malignancy or trauma presented with unprovoked seizures. He was symptom-free for 3 years but developed relapsed. Computed tomography of the brain was consistent with anaplastic convexity meningioma which was identical via intraoperative findings. However, the final histology revealed gliosarcoma of the brain. He recovered well postoperatively without any neurological deficit and had completed adjuvant chemoradiotherapy. He was asymptomatic during follow up with no tumour recurrence. Gliosarcoma with predominant sarcomatous component mimicking a meningioma has prolonged survival as compared to a case with predominant glioblastoma component. Hence, the discordance between clinical, radiological, intraoperative and histopathological findings is a challenge in establishing a diagnosis of gliosarcoma.
format Article
author Nornazirah Azizan
Nor Haizura Ab Rani
Ahmad Toha Samsudin
Fadhli Mustaffa
Firdaus Hayati
author_facet Nornazirah Azizan
Nor Haizura Ab Rani
Ahmad Toha Samsudin
Fadhli Mustaffa
Firdaus Hayati
author_sort Nornazirah Azizan
title Gliosarcoma of a brain: a challenging diagnosis
title_short Gliosarcoma of a brain: a challenging diagnosis
title_full Gliosarcoma of a brain: a challenging diagnosis
title_fullStr Gliosarcoma of a brain: a challenging diagnosis
title_full_unstemmed Gliosarcoma of a brain: a challenging diagnosis
title_sort gliosarcoma of a brain: a challenging diagnosis
publisher Universiti Malaysia Sabah
publishDate 2020
url https://eprints.ums.edu.my/id/eprint/27027/1/Gliosarcoma%20of%20a%20Brain%2C%20A%20Challenging%20Diagnosis-Abstract.pdf
https://eprints.ums.edu.my/id/eprint/27027/2/Gliosarcoma%20of%20a%20Brain%2C%20A%20Challenging%20Diagnosis.pdf
https://eprints.ums.edu.my/id/eprint/27027/
https://jurcon.ums.edu.my/ojums/index.php/bjms/article/view/2060/1744
_version_ 1760230571317919744
score 13.211869

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