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Probing nanoliposomes using single particle analytical techniques: effect of excipients, solvents, phase transition and zeta potential

There has been a steady increase in the interest towards employing nanoliposomes as colloidal drug delivery systems, particularly in the last few years. Their biocompatibility nature along with the possibility of encapsulation of lipidsoluble, water-soluble and amphipathic molecules and compounds ar...

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Main Authors: M. Danaei, M. Kalantari, M. Raji, H. Samareh Fekri, R. Saber, G. P. Asnani, S.M.Mortazavi, M. R. Mozafari, B. Rasti, A. Taheriazam
Format: Article
Language:English
Published: 2018
Subjects:
QD Chemistry
T Technology (General)
Online Access:https://eprints.ums.edu.my/id/eprint/24070/1/Probing%20nanoliposomes%20using%20single%20particle%20analytical%20techniques%20effect%20of%20excipients%2Csolvents%2C%20phase%20transition%20and%20zeta%20potential.pdf
https://eprints.ums.edu.my/id/eprint/24070/
https://doi.org/10.1016/j.heliyon.2018.e01088
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spelling my.ums.eprints.240702019-11-12T00:19:47Z https://eprints.ums.edu.my/id/eprint/24070/ Probing nanoliposomes using single particle analytical techniques: effect of excipients, solvents, phase transition and zeta potential M. Danaei M. Kalantari M. Raji H. Samareh Fekri R. Saber G. P. Asnani S.M.Mortazavi M. R. Mozafari B. Rasti A. Taheriazam QD Chemistry T Technology (General) There has been a steady increase in the interest towards employing nanoliposomes as colloidal drug delivery systems, particularly in the last few years. Their biocompatibility nature along with the possibility of encapsulation of lipidsoluble, water-soluble and amphipathic molecules and compounds are among the advantages of employing these lipidic nanocarriers. A challenge in the successful formulation of nanoliposomal systems is to control the critical physicochemical properties, which impact their in vivo performance, and validating analytical techniques that can adequately characterize these nanostructures. Of particular interest are the chemical composition of nanoliposomes, their phase transition temperature, state of the encapsulated material, encapsulation efficiency, particle size distribution, morphology, internal structure, lamellarity, surface charge, and drug release pattern. These attributes are highly important in revealing the supramolecular arrangement of nanoliposomes and incorporated drugs and ensuring the stability of the formulation as well as consistent drug delivery to target tissues. In this article, we present characterization of nanoliposomal formulations as an example to illustrate identification of key in vitro characteristics of a typical nanotherapeutic agent. Corresponding analytical techniques are discussed within the context of nanoliposome assessment, single particle analysis and ensuring uniform manufacture of therapeutic formulations with batch-to-batch consistency. 2018 Article PeerReviewed text en https://eprints.ums.edu.my/id/eprint/24070/1/Probing%20nanoliposomes%20using%20single%20particle%20analytical%20techniques%20effect%20of%20excipients%2Csolvents%2C%20phase%20transition%20and%20zeta%20potential.pdf M. Danaei and M. Kalantari and M. Raji and H. Samareh Fekri and R. Saber and G. P. Asnani and S.M.Mortazavi and M. R. Mozafari and B. Rasti and A. Taheriazam (2018) Probing nanoliposomes using single particle analytical techniques: effect of excipients, solvents, phase transition and zeta potential. https://doi.org/10.1016/j.heliyon.2018.e01088, 4 (12). pp. 1-32. https://doi.org/10.1016/j.heliyon.2018.e01088
institution Universiti Malaysia Sabah
building UMS Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Sabah
content_source UMS Institutional Repository
url_provider http://eprints.ums.edu.my/
language English
topic QD Chemistry
T Technology (General)
spellingShingle QD Chemistry
T Technology (General)
M. Danaei
M. Kalantari
M. Raji
H. Samareh Fekri
R. Saber
G. P. Asnani
S.M.Mortazavi
M. R. Mozafari
B. Rasti
A. Taheriazam
Probing nanoliposomes using single particle analytical techniques: effect of excipients, solvents, phase transition and zeta potential
description There has been a steady increase in the interest towards employing nanoliposomes as colloidal drug delivery systems, particularly in the last few years. Their biocompatibility nature along with the possibility of encapsulation of lipidsoluble, water-soluble and amphipathic molecules and compounds are among the advantages of employing these lipidic nanocarriers. A challenge in the successful formulation of nanoliposomal systems is to control the critical physicochemical properties, which impact their in vivo performance, and validating analytical techniques that can adequately characterize these nanostructures. Of particular interest are the chemical composition of nanoliposomes, their phase transition temperature, state of the encapsulated material, encapsulation efficiency, particle size distribution, morphology, internal structure, lamellarity, surface charge, and drug release pattern. These attributes are highly important in revealing the supramolecular arrangement of nanoliposomes and incorporated drugs and ensuring the stability of the formulation as well as consistent drug delivery to target tissues. In this article, we present characterization of nanoliposomal formulations as an example to illustrate identification of key in vitro characteristics of a typical nanotherapeutic agent. Corresponding analytical techniques are discussed within the context of nanoliposome assessment, single particle analysis and ensuring uniform manufacture of therapeutic formulations with batch-to-batch consistency.
format Article
author M. Danaei
M. Kalantari
M. Raji
H. Samareh Fekri
R. Saber
G. P. Asnani
S.M.Mortazavi
M. R. Mozafari
B. Rasti
A. Taheriazam
author_facet M. Danaei
M. Kalantari
M. Raji
H. Samareh Fekri
R. Saber
G. P. Asnani
S.M.Mortazavi
M. R. Mozafari
B. Rasti
A. Taheriazam
author_sort M. Danaei
title Probing nanoliposomes using single particle analytical techniques: effect of excipients, solvents, phase transition and zeta potential
title_short Probing nanoliposomes using single particle analytical techniques: effect of excipients, solvents, phase transition and zeta potential
title_full Probing nanoliposomes using single particle analytical techniques: effect of excipients, solvents, phase transition and zeta potential
title_fullStr Probing nanoliposomes using single particle analytical techniques: effect of excipients, solvents, phase transition and zeta potential
title_full_unstemmed Probing nanoliposomes using single particle analytical techniques: effect of excipients, solvents, phase transition and zeta potential
title_sort probing nanoliposomes using single particle analytical techniques: effect of excipients, solvents, phase transition and zeta potential
publishDate 2018
url https://eprints.ums.edu.my/id/eprint/24070/1/Probing%20nanoliposomes%20using%20single%20particle%20analytical%20techniques%20effect%20of%20excipients%2Csolvents%2C%20phase%20transition%20and%20zeta%20potential.pdf
https://eprints.ums.edu.my/id/eprint/24070/
https://doi.org/10.1016/j.heliyon.2018.e01088
_version_ 1760230193067196416
score 13.211869

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