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Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug

Parkinson's disease is a neurodegenerative disease caused by low dopamine levels in the brain. This study aims to obtain the optimum condition for M. pruriens extract nanoencapsulation in nano starch (NS-MPn) and nanostarch-maltodextrin (NS-MD-MPn), nanocapsules characteristics, and their poten...

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Main Authors: Sardjono, Ratnaningsih Eko, Gunawan, Ramdhan, Kadarohman, Asep, Erdiwansyah, E., Rizalman, Mamat, Melati, Khairuddean
Format: Article
Language:English
Published: Elsevier Ltd 2024
Subjects:
T Technology (General)
TA Engineering (General). Civil engineering (General)
TJ Mechanical engineering and machinery
TL Motor vehicles. Aeronautics. Astronautics
Online Access:http://umpir.ump.edu.my/id/eprint/40087/1/Nanostarch%20based%20nanoencapsulation%20of%20Mucuna%20pruriens%20extract.pdf
http://umpir.ump.edu.my/id/eprint/40087/
https://doi.org/10.1016/j.cscee.2023.100562
https://doi.org/10.1016/j.cscee.2023.100562
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spelling my.ump.umpir.400872024-01-18T06:38:45Z http://umpir.ump.edu.my/id/eprint/40087/ Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug Sardjono, Ratnaningsih Eko Gunawan, Ramdhan Kadarohman, Asep Erdiwansyah, E. Rizalman, Mamat Melati, Khairuddean T Technology (General) TA Engineering (General). Civil engineering (General) TJ Mechanical engineering and machinery TL Motor vehicles. Aeronautics. Astronautics Parkinson's disease is a neurodegenerative disease caused by low dopamine levels in the brain. This study aims to obtain the optimum condition for M. pruriens extract nanoencapsulation in nano starch (NS-MPn) and nanostarch-maltodextrin (NS-MD-MPn), nanocapsules characteristics, and their potential as anti-Parkinsonian drug. The nanoencapsulation process was carried out by ultrasonic method. FTIR, SEM, and TEM carried out the characterization of NS-MPn and NS-MD-MPn nanocapsules. Encapsulation efficiency was evaluated by UV-Vis spectroscopy. SEM and TEM characterization NS-MPn and NS-MD-MPn nanocapsules have non-spherical surface morphology, spherical in shape 234.98 and 90.85 nm, respectively. NS-MPn have 21.35% encapsulation efficiency, meanwhile, NS-MD-MPn has 30.02%. Elsevier Ltd 2024-06 Article PeerReviewed pdf en cc_by_nc_nd_4 http://umpir.ump.edu.my/id/eprint/40087/1/Nanostarch%20based%20nanoencapsulation%20of%20Mucuna%20pruriens%20extract.pdf Sardjono, Ratnaningsih Eko and Gunawan, Ramdhan and Kadarohman, Asep and Erdiwansyah, E. and Rizalman, Mamat and Melati, Khairuddean (2024) Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug. Case Studies in Chemical and Environmental Engineering, 9 (100562). pp. 1-9. ISSN 2666-0164. (Published) https://doi.org/10.1016/j.cscee.2023.100562 https://doi.org/10.1016/j.cscee.2023.100562
institution Universiti Malaysia Pahang Al-Sultan Abdullah
building UMPSA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang Al-Sultan Abdullah
content_source UMPSA Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic T Technology (General)
TA Engineering (General). Civil engineering (General)
TJ Mechanical engineering and machinery
TL Motor vehicles. Aeronautics. Astronautics
spellingShingle T Technology (General)
TA Engineering (General). Civil engineering (General)
TJ Mechanical engineering and machinery
TL Motor vehicles. Aeronautics. Astronautics
Sardjono, Ratnaningsih Eko
Gunawan, Ramdhan
Kadarohman, Asep
Erdiwansyah, E.
Rizalman, Mamat
Melati, Khairuddean
Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug
description Parkinson's disease is a neurodegenerative disease caused by low dopamine levels in the brain. This study aims to obtain the optimum condition for M. pruriens extract nanoencapsulation in nano starch (NS-MPn) and nanostarch-maltodextrin (NS-MD-MPn), nanocapsules characteristics, and their potential as anti-Parkinsonian drug. The nanoencapsulation process was carried out by ultrasonic method. FTIR, SEM, and TEM carried out the characterization of NS-MPn and NS-MD-MPn nanocapsules. Encapsulation efficiency was evaluated by UV-Vis spectroscopy. SEM and TEM characterization NS-MPn and NS-MD-MPn nanocapsules have non-spherical surface morphology, spherical in shape 234.98 and 90.85 nm, respectively. NS-MPn have 21.35% encapsulation efficiency, meanwhile, NS-MD-MPn has 30.02%.
format Article
author Sardjono, Ratnaningsih Eko
Gunawan, Ramdhan
Kadarohman, Asep
Erdiwansyah, E.
Rizalman, Mamat
Melati, Khairuddean
author_facet Sardjono, Ratnaningsih Eko
Gunawan, Ramdhan
Kadarohman, Asep
Erdiwansyah, E.
Rizalman, Mamat
Melati, Khairuddean
author_sort Sardjono, Ratnaningsih Eko
title Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug
title_short Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug
title_full Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug
title_fullStr Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug
title_full_unstemmed Nanostarch based nanoencapsulation of Mucuna pruriens extract and its evaluation as anti-parkinsonian drug
title_sort nanostarch based nanoencapsulation of mucuna pruriens extract and its evaluation as anti-parkinsonian drug
publisher Elsevier Ltd
publishDate 2024
url http://umpir.ump.edu.my/id/eprint/40087/1/Nanostarch%20based%20nanoencapsulation%20of%20Mucuna%20pruriens%20extract.pdf
http://umpir.ump.edu.my/id/eprint/40087/
https://doi.org/10.1016/j.cscee.2023.100562
https://doi.org/10.1016/j.cscee.2023.100562
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score 13.232414

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