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Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes

This present study investigated the effect of Captisol, a chemically modified cyclodextrin, on the in vitro dissolution of glimepiride. We prepared glimepiride–Captisol complexes of different mass ratios (1:1, 1:2, and 1:3 w/w) by a physical mixing or freeze-drying technique, and found that complexa...

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Main Authors: Pal, Arpita, Roy, Sudeep, Kumar, Akhil, Mahmood, Syed, Nasrin, Khodapanah, Thomas, Sabu, Agatemor, Christian, Ghosal, Kajal
Format: Article
Language:English
Published: American Chemical Society 2020
Subjects:
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/31392/1/Physicochemical%20characterization%20molecular%20docking%2C%20and%20in%20vitro%20dissolution.pdf
http://umpir.ump.edu.my/id/eprint/31392/
https://doi.org/10.1021/acsomega.0c01228
https://doi.org/10.1021/acsomega.0c01228
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spelling my.ump.umpir.313922021-07-09T02:27:05Z http://umpir.ump.edu.my/id/eprint/31392/ Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes Pal, Arpita Roy, Sudeep Kumar, Akhil Mahmood, Syed Nasrin, Khodapanah Thomas, Sabu Agatemor, Christian Ghosal, Kajal TP Chemical technology This present study investigated the effect of Captisol, a chemically modified cyclodextrin, on the in vitro dissolution of glimepiride. We prepared glimepiride–Captisol complexes of different mass ratios (1:1, 1:2, and 1:3 w/w) by a physical mixing or freeze-drying technique, and found that complexation with Captisol enhanced the water solubility of glimepiride. Molecular docking and dynamic simulation predicted complex formation; at the same time, Fourier transform infrared spectroscopy, differential scanning calorimetry, powder X-ray diffractometry, and scanning electron microscope indicated molecular interactions that support complexation. We also found that an inclusion complex was better than a physical mixture in enhancing the complexation of glimepiride with Captisol and enhancing water solubility. Phase solubility study of the glimepiride–Captisol complex showed an AL-type profile, implying the formation of a 1:1 inclusion complex. The study also revealed that pH influenced the stability of the complex because the stability constant of the glimepiride–Captisol complex was higher in distilled water of pH ∼6.0 than in phosphate buffer of pH 7.2. American Chemical Society 2020-08-18 Article PeerReviewed pdf en http://umpir.ump.edu.my/id/eprint/31392/1/Physicochemical%20characterization%20molecular%20docking%2C%20and%20in%20vitro%20dissolution.pdf Pal, Arpita and Roy, Sudeep and Kumar, Akhil and Mahmood, Syed and Nasrin, Khodapanah and Thomas, Sabu and Agatemor, Christian and Ghosal, Kajal (2020) Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes. ACS Omega, 5 (32). pp. 19968-19977. ISSN 2470-1343 https://doi.org/10.1021/acsomega.0c01228 https://doi.org/10.1021/acsomega.0c01228
institution Universiti Malaysia Pahang
building UMP Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Pahang
content_source UMP Institutional Repository
url_provider http://umpir.ump.edu.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Pal, Arpita
Roy, Sudeep
Kumar, Akhil
Mahmood, Syed
Nasrin, Khodapanah
Thomas, Sabu
Agatemor, Christian
Ghosal, Kajal
Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes
description This present study investigated the effect of Captisol, a chemically modified cyclodextrin, on the in vitro dissolution of glimepiride. We prepared glimepiride–Captisol complexes of different mass ratios (1:1, 1:2, and 1:3 w/w) by a physical mixing or freeze-drying technique, and found that complexation with Captisol enhanced the water solubility of glimepiride. Molecular docking and dynamic simulation predicted complex formation; at the same time, Fourier transform infrared spectroscopy, differential scanning calorimetry, powder X-ray diffractometry, and scanning electron microscope indicated molecular interactions that support complexation. We also found that an inclusion complex was better than a physical mixture in enhancing the complexation of glimepiride with Captisol and enhancing water solubility. Phase solubility study of the glimepiride–Captisol complex showed an AL-type profile, implying the formation of a 1:1 inclusion complex. The study also revealed that pH influenced the stability of the complex because the stability constant of the glimepiride–Captisol complex was higher in distilled water of pH ∼6.0 than in phosphate buffer of pH 7.2.
format Article
author Pal, Arpita
Roy, Sudeep
Kumar, Akhil
Mahmood, Syed
Nasrin, Khodapanah
Thomas, Sabu
Agatemor, Christian
Ghosal, Kajal
author_facet Pal, Arpita
Roy, Sudeep
Kumar, Akhil
Mahmood, Syed
Nasrin, Khodapanah
Thomas, Sabu
Agatemor, Christian
Ghosal, Kajal
author_sort Pal, Arpita
title Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes
title_short Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes
title_full Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes
title_fullStr Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes
title_full_unstemmed Physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes
title_sort physicochemical characterization, molecular docking, and in vitro dissolution of glimepiride–captisol inclusion complexes
publisher American Chemical Society
publishDate 2020
url http://umpir.ump.edu.my/id/eprint/31392/1/Physicochemical%20characterization%20molecular%20docking%2C%20and%20in%20vitro%20dissolution.pdf
http://umpir.ump.edu.my/id/eprint/31392/
https://doi.org/10.1021/acsomega.0c01228
https://doi.org/10.1021/acsomega.0c01228
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score 13.22586

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