Inhibition of nitric oxide and prostaglandin E2 production by pyrrolylated-chalcones : synthesis, biological activity, crystal structure analysis, and molecular docking studies
In search of potent anti-inflammatory agents, twenty-four chalcone derivatives including seven new compounds (13 – 17, 21 and 23) containing pyrrole moiety were designed, synthesized, and assessed for their nitric oxide (NO) and prostaglandin E2 (PGE2) suppression ability on IFN-γ/LPS-induced RAW 26...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Academic Press Inc.
2020
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| Subjects: | |
| Online Access: | http://umpir.ump.edu.my/id/eprint/27773/1/Inhibition%20of%20nitric%20oxide%20and%20prostaglandin%20E2%20production%20.pdf http://umpir.ump.edu.my/id/eprint/27773/ https://doi.org/10.1016/j.bioorg.2019.103376 https://doi.org/10.1016/j.bioorg.2019.103376 |
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