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Inhibition of nitric oxide and prostaglandin E2 production by pyrrolylated-chalcones : synthesis, biological activity, crystal structure analysis, and molecular docking studies

In search of potent anti-inflammatory agents, twenty-four chalcone derivatives including seven new compounds (13 – 17, 21 and 23) containing pyrrole moiety were designed, synthesized, and assessed for their nitric oxide (NO) and prostaglandin E2 (PGE2) suppression ability on IFN-γ/LPS-induced RAW 26...

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Bibliographic Details
Main Authors: Siti Munirah, Mohd Faudzi, Maryam Aisyah, Abdullah, Mohd Rashidi, Abdull Manap, Ahmad Zaidi, Ismail, Kamal, Rullah, Mohd F. F., Mohd Aluwi, Aizi Nor Mazila, Ramli, Faridah, Abas, Nordin, Lajis
Format: Article
Language:English
Published: Academic Press Inc. 2020
Subjects:
TP Chemical technology
Online Access:http://umpir.ump.edu.my/id/eprint/27773/1/Inhibition%20of%20nitric%20oxide%20and%20prostaglandin%20E2%20production%20.pdf
http://umpir.ump.edu.my/id/eprint/27773/
https://doi.org/10.1016/j.bioorg.2019.103376
https://doi.org/10.1016/j.bioorg.2019.103376
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http://umpir.ump.edu.my/id/eprint/27773/1/Inhibition%20of%20nitric%20oxide%20and%20prostaglandin%20E2%20production%20.pdf
http://umpir.ump.edu.my/id/eprint/27773/
https://doi.org/10.1016/j.bioorg.2019.103376
https://doi.org/10.1016/j.bioorg.2019.103376

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