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Formulation and characterization of Piper belle nanoemulgel for anti-microbial activities

The aim of this study was to formulate and characterize the nanoemulgel containing Piper betle essential oil. The nanoemulgel was formulated using blank nanoemulsion (FO), nanoemulsion with 1:4 (F1) and 4:1 (F2) ratio of soybean oil to Piper betle oil and thickening agent. The formulation of nanoemu...

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Main Author: Amat Rahim, Nor Fadiana
Format: Undergraduate Final Project Report
Published: 2020
Online Access:http://discol.umk.edu.my/id/eprint/4110/
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spelling my.umk.eprints.41102022-05-23T08:22:41Z http://discol.umk.edu.my/id/eprint/4110/ Formulation and characterization of Piper belle nanoemulgel for anti-microbial activities Amat Rahim, Nor Fadiana The aim of this study was to formulate and characterize the nanoemulgel containing Piper betle essential oil. The nanoemulgel was formulated using blank nanoemulsion (FO), nanoemulsion with 1:4 (F1) and 4:1 (F2) ratio of soybean oil to Piper betle oil and thickening agent. The formulation of nanoemulgel was done based on the ternary phase diagram from the previous study that produced a large nanoemulsion region. The essential oil of Piper betle was extracted by using steam distillation method and analysed by using Fourier Transform Infrared (FTIR) to observe the functional group present. The mean droplet size of nanoemulsion were 41.00 nm, 161.05nm, and 27.67 nm for FO, Fl, and F2 respectively. It was confirmed by Dynamic Light Scattering (DLS). Nanoemulsion and nanoemulgel were characterised by using Tyndall effect, physical appearance test, spreadability test and pH test. The Piper betle nanoemulgel produced was tested on Staphylococcus aureus to investigate its affectiveness on antimicrobial activity. The antimicrobial assay test was conducted to measure the diameter of inhibition zone of Staphylococcus aureus. The statistical analysis shows that there was a significant differences between the groups (p < 0.05). Nanoemulgel can be used to serve a better stability, permeation and suitable viscosity for the delivery of drugs. Nanoemulgel can influences a better skin penetration as it consist of small droplets size containing essential oil as the active ingredient. 2020 Undergraduate Final Project Report NonPeerReviewed Amat Rahim, Nor Fadiana (2020) Formulation and characterization of Piper belle nanoemulgel for anti-microbial activities. Final Year Project thesis, Universiti Malaysia Kelantan. (Submitted)
institution Universiti Malaysia Kelantan
building Perpustakaan Universiti Malaysia Kelantan
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaysia Kelantan
content_source UMK Institutional Repository
url_provider http://umkeprints.umk.edu.my/
description The aim of this study was to formulate and characterize the nanoemulgel containing Piper betle essential oil. The nanoemulgel was formulated using blank nanoemulsion (FO), nanoemulsion with 1:4 (F1) and 4:1 (F2) ratio of soybean oil to Piper betle oil and thickening agent. The formulation of nanoemulgel was done based on the ternary phase diagram from the previous study that produced a large nanoemulsion region. The essential oil of Piper betle was extracted by using steam distillation method and analysed by using Fourier Transform Infrared (FTIR) to observe the functional group present. The mean droplet size of nanoemulsion were 41.00 nm, 161.05nm, and 27.67 nm for FO, Fl, and F2 respectively. It was confirmed by Dynamic Light Scattering (DLS). Nanoemulsion and nanoemulgel were characterised by using Tyndall effect, physical appearance test, spreadability test and pH test. The Piper betle nanoemulgel produced was tested on Staphylococcus aureus to investigate its affectiveness on antimicrobial activity. The antimicrobial assay test was conducted to measure the diameter of inhibition zone of Staphylococcus aureus. The statistical analysis shows that there was a significant differences between the groups (p < 0.05). Nanoemulgel can be used to serve a better stability, permeation and suitable viscosity for the delivery of drugs. Nanoemulgel can influences a better skin penetration as it consist of small droplets size containing essential oil as the active ingredient.
format Undergraduate Final Project Report
author Amat Rahim, Nor Fadiana
spellingShingle Amat Rahim, Nor Fadiana
Formulation and characterization of Piper belle nanoemulgel for anti-microbial activities
author_facet Amat Rahim, Nor Fadiana
author_sort Amat Rahim, Nor Fadiana
title Formulation and characterization of Piper belle nanoemulgel for anti-microbial activities
title_short Formulation and characterization of Piper belle nanoemulgel for anti-microbial activities
title_full Formulation and characterization of Piper belle nanoemulgel for anti-microbial activities
title_fullStr Formulation and characterization of Piper belle nanoemulgel for anti-microbial activities
title_full_unstemmed Formulation and characterization of Piper belle nanoemulgel for anti-microbial activities
title_sort formulation and characterization of piper belle nanoemulgel for anti-microbial activities
publishDate 2020
url http://discol.umk.edu.my/id/eprint/4110/
_version_ 1763303367921106944
score 13.244368

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