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Microfibrillated cellulose-reinforced alginate microbeads for delivery of palm-based vitamin E: Characterizations and in vitro evaluation

In this study, palm-based vitamin E-loaded emulsions were immobilized within microfibrillated cellulose-reinforced alginate microbeads by dripping vitamin E-loaded emulsions into the crosslinking solution. FTIR spectrum of crosslinked microbeads demonstrated the characteristic peaks of vitamin E at...

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Main Authors: Goh, Kar Yin, Ching, Yern Chee, Ng, Mei Han, Chuah, Cheng Hock, Julai @ Julaihi, Sabariah
Format: Article
Published: Elsevier 2022
Subjects:
QD Chemistry
S Agriculture (General)
TP Chemical technology
Online Access:http://eprints.um.edu.my/42215/
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spelling my.um.eprints.422152023-10-17T06:27:22Z http://eprints.um.edu.my/42215/ Microfibrillated cellulose-reinforced alginate microbeads for delivery of palm-based vitamin E: Characterizations and in vitro evaluation Goh, Kar Yin Ching, Yern Chee Ng, Mei Han Chuah, Cheng Hock Julai @ Julaihi, Sabariah QD Chemistry S Agriculture (General) TP Chemical technology In this study, palm-based vitamin E-loaded emulsions were immobilized within microfibrillated cellulose-reinforced alginate microbeads by dripping vitamin E-loaded emulsions into the crosslinking solution. FTIR spectrum of crosslinked microbeads demonstrated the characteristic peaks of vitamin E at 1447, 1380, 1255, 1096 and 944 cm(-1), implying the entrapment of the therapeutic agent. The microbeads were observed to be spherical under SEM and the external surfaces of the microbeads were rough with visible wrinkles. Results showed that highest compressive strength of 58.8 kPa was obtained for alginate microbeads containing Tween 80:Brij 35-stabilized emulsions with 0.25% w/v hydrophilic oxidized celluloses. This indicated that ammonium persulfate-oxidized celluloses participate in the formation of densely packed and three-dimensional matrix structures of microbeads by interacting with calcium ions via their -COO- groups. Likewise, the highest encapsulation efficiency of 98.7% was also achieved by the 0.25% ammonium persulfate-oxidized cellulose reinforced alginate microbeads containing Tween 80:Brij 35-stabilized emulsion. In addition, the alginate/microfibrillated cellulose microbeads were more resistant against swelling in low pH condition because of the enhanced stability promoted by the biobased microfibrillated celluloses. The microbeads showed slow release of vitamin E in the simulated gastric pH fluid but tend to release in the simulated intestinal pH fluid to allow the absorption of the drug. Elsevier 2022-05 Article PeerReviewed Goh, Kar Yin and Ching, Yern Chee and Ng, Mei Han and Chuah, Cheng Hock and Julai @ Julaihi, Sabariah (2022) Microfibrillated cellulose-reinforced alginate microbeads for delivery of palm-based vitamin E: Characterizations and in vitro evaluation. Journal Of Drug Delivery Science And Technology, 71. ISSN 1773-2247, DOI https://doi.org/10.1016/j.jddst.2022.103324 <https://doi.org/10.1016/j.jddst.2022.103324>. 10.1016/j.jddst.2022.103324
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
S Agriculture (General)
TP Chemical technology
spellingShingle QD Chemistry
S Agriculture (General)
TP Chemical technology
Goh, Kar Yin
Ching, Yern Chee
Ng, Mei Han
Chuah, Cheng Hock
Julai @ Julaihi, Sabariah
Microfibrillated cellulose-reinforced alginate microbeads for delivery of palm-based vitamin E: Characterizations and in vitro evaluation
description In this study, palm-based vitamin E-loaded emulsions were immobilized within microfibrillated cellulose-reinforced alginate microbeads by dripping vitamin E-loaded emulsions into the crosslinking solution. FTIR spectrum of crosslinked microbeads demonstrated the characteristic peaks of vitamin E at 1447, 1380, 1255, 1096 and 944 cm(-1), implying the entrapment of the therapeutic agent. The microbeads were observed to be spherical under SEM and the external surfaces of the microbeads were rough with visible wrinkles. Results showed that highest compressive strength of 58.8 kPa was obtained for alginate microbeads containing Tween 80:Brij 35-stabilized emulsions with 0.25% w/v hydrophilic oxidized celluloses. This indicated that ammonium persulfate-oxidized celluloses participate in the formation of densely packed and three-dimensional matrix structures of microbeads by interacting with calcium ions via their -COO- groups. Likewise, the highest encapsulation efficiency of 98.7% was also achieved by the 0.25% ammonium persulfate-oxidized cellulose reinforced alginate microbeads containing Tween 80:Brij 35-stabilized emulsion. In addition, the alginate/microfibrillated cellulose microbeads were more resistant against swelling in low pH condition because of the enhanced stability promoted by the biobased microfibrillated celluloses. The microbeads showed slow release of vitamin E in the simulated gastric pH fluid but tend to release in the simulated intestinal pH fluid to allow the absorption of the drug.
format Article
author Goh, Kar Yin
Ching, Yern Chee
Ng, Mei Han
Chuah, Cheng Hock
Julai @ Julaihi, Sabariah
author_facet Goh, Kar Yin
Ching, Yern Chee
Ng, Mei Han
Chuah, Cheng Hock
Julai @ Julaihi, Sabariah
author_sort Goh, Kar Yin
title Microfibrillated cellulose-reinforced alginate microbeads for delivery of palm-based vitamin E: Characterizations and in vitro evaluation
title_short Microfibrillated cellulose-reinforced alginate microbeads for delivery of palm-based vitamin E: Characterizations and in vitro evaluation
title_full Microfibrillated cellulose-reinforced alginate microbeads for delivery of palm-based vitamin E: Characterizations and in vitro evaluation
title_fullStr Microfibrillated cellulose-reinforced alginate microbeads for delivery of palm-based vitamin E: Characterizations and in vitro evaluation
title_full_unstemmed Microfibrillated cellulose-reinforced alginate microbeads for delivery of palm-based vitamin E: Characterizations and in vitro evaluation
title_sort microfibrillated cellulose-reinforced alginate microbeads for delivery of palm-based vitamin e: characterizations and in vitro evaluation
publisher Elsevier
publishDate 2022
url http://eprints.um.edu.my/42215/
_version_ 1781704611291201536
score 13.211869

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