Cover Image

A bioanalytical method for quantification of telmisartan in rat plasma; development, validation and application to pharmacokinetic study

The telmisartan was determined in a rat plasma using developed and validated a reversed-phase high performance liquid chromatographic (HPLC). The pre-treatment of the plasma sample involving liquid-liquid extraction using ethanol as the extracting solvent. The HPLC method validation has been shown a...

Full description

Saved in:
Bibliographic Details
Main Authors: Al-Japairai, K.A.S., Chatterjee, B., Mahmood, Syed, Almurisi, S.H.
Format: Article
Published: 2021
Subjects:
RS Pharmacy and materia medica
Online Access:http://eprints.um.edu.my/35473/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108295714&doi=10.52711%2f0974-360X.2021.00379&partnerID=40&md5=034635993c3af6155b22906ec0c00b34
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.um.eprints.35473
record_format eprints
spelling my.um.eprints.354732023-10-09T08:05:52Z http://eprints.um.edu.my/35473/ A bioanalytical method for quantification of telmisartan in rat plasma; development, validation and application to pharmacokinetic study Al-Japairai, K.A.S. Chatterjee, B. Mahmood, Syed Almurisi, S.H. RS Pharmacy and materia medica The telmisartan was determined in a rat plasma using developed and validated a reversed-phase high performance liquid chromatographic (HPLC). The pre-treatment of the plasma sample involving liquid-liquid extraction using ethanol as the extracting solvent. The HPLC method validation has been shown a linear calibration curve over a plasma concentrations range of 0.7 to 10µg/mL with a correlation coefficient of 0.9979, the limit of detection and the limit of quantification were determined to be 0.025µg/ml and 0.07µg/ml, respectively. The precision and accuracy were in an acceptable limit. The pharmacokinetic parameters of telmisartan were adequately evaluated following a single oral dose (4mg/kg) in Sprague-Dawley rats. The results observed conclude that the developed bioanalytical HPLC method is appropriate and applicable as an analytical tool in the pharmacokinetic study of telmisartan. © RJPT All right reserved. 2021 Article PeerReviewed Al-Japairai, K.A.S. and Chatterjee, B. and Mahmood, Syed and Almurisi, S.H. (2021) A bioanalytical method for quantification of telmisartan in rat plasma; development, validation and application to pharmacokinetic study. Research Journal of Pharmacy and Technology, 14 (4). pp. 2139-2144. ISSN 0974-3618, DOI https://doi.org/10.52711/0974-360X.2021.00379 <https://doi.org/10.52711/0974-360X.2021.00379>. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108295714&doi=10.52711%2f0974-360X.2021.00379&partnerID=40&md5=034635993c3af6155b22906ec0c00b34 10.52711/0974-360X.2021.00379
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Al-Japairai, K.A.S.
Chatterjee, B.
Mahmood, Syed
Almurisi, S.H.
A bioanalytical method for quantification of telmisartan in rat plasma; development, validation and application to pharmacokinetic study
description The telmisartan was determined in a rat plasma using developed and validated a reversed-phase high performance liquid chromatographic (HPLC). The pre-treatment of the plasma sample involving liquid-liquid extraction using ethanol as the extracting solvent. The HPLC method validation has been shown a linear calibration curve over a plasma concentrations range of 0.7 to 10µg/mL with a correlation coefficient of 0.9979, the limit of detection and the limit of quantification were determined to be 0.025µg/ml and 0.07µg/ml, respectively. The precision and accuracy were in an acceptable limit. The pharmacokinetic parameters of telmisartan were adequately evaluated following a single oral dose (4mg/kg) in Sprague-Dawley rats. The results observed conclude that the developed bioanalytical HPLC method is appropriate and applicable as an analytical tool in the pharmacokinetic study of telmisartan. © RJPT All right reserved.
format Article
author Al-Japairai, K.A.S.
Chatterjee, B.
Mahmood, Syed
Almurisi, S.H.
author_facet Al-Japairai, K.A.S.
Chatterjee, B.
Mahmood, Syed
Almurisi, S.H.
author_sort Al-Japairai, K.A.S.
title A bioanalytical method for quantification of telmisartan in rat plasma; development, validation and application to pharmacokinetic study
title_short A bioanalytical method for quantification of telmisartan in rat plasma; development, validation and application to pharmacokinetic study
title_full A bioanalytical method for quantification of telmisartan in rat plasma; development, validation and application to pharmacokinetic study
title_fullStr A bioanalytical method for quantification of telmisartan in rat plasma; development, validation and application to pharmacokinetic study
title_full_unstemmed A bioanalytical method for quantification of telmisartan in rat plasma; development, validation and application to pharmacokinetic study
title_sort bioanalytical method for quantification of telmisartan in rat plasma; development, validation and application to pharmacokinetic study
publishDate 2021
url http://eprints.um.edu.my/35473/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108295714&doi=10.52711%2f0974-360X.2021.00379&partnerID=40&md5=034635993c3af6155b22906ec0c00b34
_version_ 1781704472600248320
score 13.211869

Similar Items