RAS-protein activation but not mutation status is an outcome predictor and unifying therapeutic target for high-risk acute lymphoblastic leukemia
Leukemias are routinely sub-typed for risk/outcome prediction and therapy choice using acquired mutations and chromosomal rearrangements. Down syndrome acute lymphoblastic leukemia (DS-ALL) is characterized by high frequency of CRLF2-rearrangements, JAK2-mutations, or RAS-pathway mutations. Intrigui...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Published: |
Springer Nature
2021
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/34530/ |
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