RAS-protein activation but not mutation status is an outcome predictor and unifying therapeutic target for high-risk acute lymphoblastic leukemia
Leukemias are routinely sub-typed for risk/outcome prediction and therapy choice using acquired mutations and chromosomal rearrangements. Down syndrome acute lymphoblastic leukemia (DS-ALL) is characterized by high frequency of CRLF2-rearrangements, JAK2-mutations, or RAS-pathway mutations. Intrigui...
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Main Authors: | Koschut, David, Ray, Debleena, Li, Zhenhua, Giarin, Emanuela, Groet, Jurgen, Alic, Ivan, Kham, Shirley Kow-Yin, Chng, Wee Joo, Ariffin, Hany Mohd, Weinstock, David M., Yeoh, Allen Eng-Juh, Basso, Giuseppe, Nizetic, Dean |
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Format: | Article |
Published: |
Springer Nature
2021
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Online Access: | http://eprints.um.edu.my/34530/ |
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