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Multivariate regression between hounsfield unit shift, tissue temperature, and tissue contraction: A feasibility study of computed tomography thermometry

This study aims to determine the relationship between Hounsfield Unit shift (Delta HU), tissue temperature change (Delta T), and tissue's relative cross-sectional area change (Delta A) of ex vivo bovine liver tissues. The fresh bovine livers (n = 3) were heated from 21 degrees C to 100 degrees...

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Main Authors: Tan, Daryl, Lim, Kok-Sing, Wong, Yin-How, Abd Raziff, Hani Hareiza, Tan, Soon-Hao, Sulaiman, Norshazriman, Abdullah, Basri Johan Jeet, Ahmad, Harith, Yeong, Chai-Hong
Format: Article
Published: IEEE-Inst Electrical Electronics Engineers Inc 2021
Subjects:
R Medicine
R Medicine (General)
TA Engineering (General). Civil engineering (General)
Online Access:http://eprints.um.edu.my/34285/
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spelling my.um.eprints.342852022-09-09T07:40:18Z http://eprints.um.edu.my/34285/ Multivariate regression between hounsfield unit shift, tissue temperature, and tissue contraction: A feasibility study of computed tomography thermometry Tan, Daryl Lim, Kok-Sing Wong, Yin-How Abd Raziff, Hani Hareiza Tan, Soon-Hao Sulaiman, Norshazriman Abdullah, Basri Johan Jeet Ahmad, Harith Yeong, Chai-Hong R Medicine R Medicine (General) TA Engineering (General). Civil engineering (General) This study aims to determine the relationship between Hounsfield Unit shift (Delta HU), tissue temperature change (Delta T), and tissue's relative cross-sectional area change (Delta A) of ex vivo bovine liver tissues. The fresh bovine livers (n = 3) were heated from 21 degrees C to 100 degrees C within 24 min using a custom-made ceramic hot plate and left for cooling to room temperature (Delta 70 min). HU and tissue temperature measurement were obtained at 3-min intervals during the experiment. After that, the cross-sectional tissue area changes, and Delta A was calculated. Finally, a multivariate linear regression analysis was performed to determine the relationship between Delta HU, Delta T, and Delta A. The results were compared with that of the conventional Delta HU-Delta T linear model. Tissues that underwent a larger thermal dose experienced a higher degree of tissue contraction, an irreversible process that contributed to the non-linear behavior in the Delta HU-Delta T characteristic curve. This finding was in agreement with the histological test, in which the tissues nearer to the heat source had higher cell counts than those farther away. A phenomenological equation for Delta HU in the function of Delta T and Delta A shows better regression with the experimental data (R-2 is an element of 0.838, 0.977]) than the conventional Delta HU-Delta T linear model. This finding indicates that tissue contraction is an important parameter to be considered in the development of CT thermometry. The Delta HU-Delta T-Delta A characteristic equation presented in this work offers accurate estimation of tissue temperature based on the HU change and magnitude of tissue contraction during a CT-guided thermal ablation procedure. IEEE-Inst Electrical Electronics Engineers Inc 2021 Article PeerReviewed Tan, Daryl and Lim, Kok-Sing and Wong, Yin-How and Abd Raziff, Hani Hareiza and Tan, Soon-Hao and Sulaiman, Norshazriman and Abdullah, Basri Johan Jeet and Ahmad, Harith and Yeong, Chai-Hong (2021) Multivariate regression between hounsfield unit shift, tissue temperature, and tissue contraction: A feasibility study of computed tomography thermometry. IEEE Transactions on Instrumentation and Measurement, 70. ISSN 0018-9456, DOI https://doi.org/10.1109/TIM.2021.3075019 <https://doi.org/10.1109/TIM.2021.3075019>. 10.1109/TIM.2021.3075019
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
R Medicine (General)
TA Engineering (General). Civil engineering (General)
spellingShingle R Medicine
R Medicine (General)
TA Engineering (General). Civil engineering (General)
Tan, Daryl
Lim, Kok-Sing
Wong, Yin-How
Abd Raziff, Hani Hareiza
Tan, Soon-Hao
Sulaiman, Norshazriman
Abdullah, Basri Johan Jeet
Ahmad, Harith
Yeong, Chai-Hong
Multivariate regression between hounsfield unit shift, tissue temperature, and tissue contraction: A feasibility study of computed tomography thermometry
description This study aims to determine the relationship between Hounsfield Unit shift (Delta HU), tissue temperature change (Delta T), and tissue's relative cross-sectional area change (Delta A) of ex vivo bovine liver tissues. The fresh bovine livers (n = 3) were heated from 21 degrees C to 100 degrees C within 24 min using a custom-made ceramic hot plate and left for cooling to room temperature (Delta 70 min). HU and tissue temperature measurement were obtained at 3-min intervals during the experiment. After that, the cross-sectional tissue area changes, and Delta A was calculated. Finally, a multivariate linear regression analysis was performed to determine the relationship between Delta HU, Delta T, and Delta A. The results were compared with that of the conventional Delta HU-Delta T linear model. Tissues that underwent a larger thermal dose experienced a higher degree of tissue contraction, an irreversible process that contributed to the non-linear behavior in the Delta HU-Delta T characteristic curve. This finding was in agreement with the histological test, in which the tissues nearer to the heat source had higher cell counts than those farther away. A phenomenological equation for Delta HU in the function of Delta T and Delta A shows better regression with the experimental data (R-2 is an element of 0.838, 0.977]) than the conventional Delta HU-Delta T linear model. This finding indicates that tissue contraction is an important parameter to be considered in the development of CT thermometry. The Delta HU-Delta T-Delta A characteristic equation presented in this work offers accurate estimation of tissue temperature based on the HU change and magnitude of tissue contraction during a CT-guided thermal ablation procedure.
format Article
author Tan, Daryl
Lim, Kok-Sing
Wong, Yin-How
Abd Raziff, Hani Hareiza
Tan, Soon-Hao
Sulaiman, Norshazriman
Abdullah, Basri Johan Jeet
Ahmad, Harith
Yeong, Chai-Hong
author_facet Tan, Daryl
Lim, Kok-Sing
Wong, Yin-How
Abd Raziff, Hani Hareiza
Tan, Soon-Hao
Sulaiman, Norshazriman
Abdullah, Basri Johan Jeet
Ahmad, Harith
Yeong, Chai-Hong
author_sort Tan, Daryl
title Multivariate regression between hounsfield unit shift, tissue temperature, and tissue contraction: A feasibility study of computed tomography thermometry
title_short Multivariate regression between hounsfield unit shift, tissue temperature, and tissue contraction: A feasibility study of computed tomography thermometry
title_full Multivariate regression between hounsfield unit shift, tissue temperature, and tissue contraction: A feasibility study of computed tomography thermometry
title_fullStr Multivariate regression between hounsfield unit shift, tissue temperature, and tissue contraction: A feasibility study of computed tomography thermometry
title_full_unstemmed Multivariate regression between hounsfield unit shift, tissue temperature, and tissue contraction: A feasibility study of computed tomography thermometry
title_sort multivariate regression between hounsfield unit shift, tissue temperature, and tissue contraction: a feasibility study of computed tomography thermometry
publisher IEEE-Inst Electrical Electronics Engineers Inc
publishDate 2021
url http://eprints.um.edu.my/34285/
_version_ 1744649169497227264
score 13.211869

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