Multivariate regression between hounsfield unit shift, tissue temperature, and tissue contraction: A feasibility study of computed tomography thermometry
This study aims to determine the relationship between Hounsfield Unit shift (Delta HU), tissue temperature change (Delta T), and tissue's relative cross-sectional area change (Delta A) of ex vivo bovine liver tissues. The fresh bovine livers (n = 3) were heated from 21 degrees C to 100 degrees...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Published: |
IEEE-Inst Electrical Electronics Engineers Inc
2021
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/34285/ |
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| Summary: | This study aims to determine the relationship between Hounsfield Unit shift (Delta HU), tissue temperature change (Delta T), and tissue's relative cross-sectional area change (Delta A) of ex vivo bovine liver tissues. The fresh bovine livers (n = 3) were heated from 21 degrees C to 100 degrees C within 24 min using a custom-made ceramic hot plate and left for cooling to room temperature (Delta 70 min). HU and tissue temperature measurement were obtained at 3-min intervals during the experiment. After that, the cross-sectional tissue area changes, and Delta A was calculated. Finally, a multivariate linear regression analysis was performed to determine the relationship between Delta HU, Delta T, and Delta A. The results were compared with that of the conventional Delta HU-Delta T linear model. Tissues that underwent a larger thermal dose experienced a higher degree of tissue contraction, an irreversible process that contributed to the non-linear behavior in the Delta HU-Delta T characteristic curve. This finding was in agreement with the histological test, in which the tissues nearer to the heat source had higher cell counts than those farther away. A phenomenological equation for Delta HU in the function of Delta T and Delta A shows better regression with the experimental data (R-2 is an element of 0.838, 0.977]) than the conventional Delta HU-Delta T linear model. This finding indicates that tissue contraction is an important parameter to be considered in the development of CT thermometry. The Delta HU-Delta T-Delta A characteristic equation presented in this work offers accurate estimation of tissue temperature based on the HU change and magnitude of tissue contraction during a CT-guided thermal ablation procedure. |
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