Staff View: Natural DENV-2 NS2B/NS3 protease inhibitors from Myristica cinnamomea King

Natural DENV-2 NS2B/NS3 protease inhibitors from Myristica cinnamomea King

The NS2B/NS3 protease is crucial for the pathogenesis of the DENV. Therefore, the inhibition of this protease is considered to be the key strategy for the development of new antiviral drugs. In the present study, malabaricones C (3) and E (4), acylphenols from the fruits of Myristica cinnamomea King...

Full description

Saved in:

Bibliographic Details
Main Authors:	Sivasothy, Y., Liew, S. Y., Othman, M. A., Wahab, Abdul S. M., Hariono, M., Nawi, Mohd M. S., Wahab, Abdul H., Awang, K.
Format:	Article
Published:	Malaysian Soc Parasitology Tropical Medicine 2021
Subjects:	RM Therapeutics. Pharmacology Materia medica and therapeutic
Online Access:	http://eprints.um.edu.my/34014/
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my.um.eprints.34014
record_format	eprints
spelling	my.um.eprints.340142022-06-24T02:06:53Z http://eprints.um.edu.my/34014/ Natural DENV-2 NS2B/NS3 protease inhibitors from Myristica cinnamomea King Sivasothy, Y. Liew, S. Y. Othman, M. A. Wahab, Abdul S. M. Hariono, M. Nawi, Mohd M. S. Wahab, Abdul H. Awang, K. RM Therapeutics. Pharmacology Materia medica and therapeutic The NS2B/NS3 protease is crucial for the pathogenesis of the DENV. Therefore, the inhibition of this protease is considered to be the key strategy for the development of new antiviral drugs. In the present study, malabaricones C (3) and E (4), acylphenols from the fruits of Myristica cinnamomea King, have been respectively identified as moderate (27.33 +/- 5.45 mu M) and potent (7.55 +/- 1.64 mu M) DENV-2 NS2B/NS3 protease inhibitors, thus making this the first report on the DENV-2 NS2B/NS3 protease inhibitory activity of acylphenols. Based on the molecular docking studies, compounds 3 and 4 both have pi-pi interactions with Tyr161. While compound 3 has hydrogen bonding interactions with Gly151, Gly153 and Tyr161, compound 4 however, forms hydrogen bonds with Ser135, Asp129, Phe130 and Ile86 instead. The results from the present study suggests that malabaricones C (3) and E (4) could be employed as lead compounds for the development of new dengue antivirals from natural origin. Malaysian Soc Parasitology Tropical Medicine 2021-06 Article PeerReviewed Sivasothy, Y. and Liew, S. Y. and Othman, M. A. and Wahab, Abdul S. M. and Hariono, M. and Nawi, Mohd M. S. and Wahab, Abdul H. and Awang, K. (2021) Natural DENV-2 NS2B/NS3 protease inhibitors from Myristica cinnamomea King. Tropical Biomedicine, 38 (2). pp. 79-84. ISSN 0127-5720, DOI https://doi.org/10.47665/tb.38.2.044 <https://doi.org/10.47665/tb.38.2.044>. 10.47665/tb.38.2.044
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	RM Therapeutics. Pharmacology Materia medica and therapeutic
spellingShingle	RM Therapeutics. Pharmacology Materia medica and therapeutic Sivasothy, Y. Liew, S. Y. Othman, M. A. Wahab, Abdul S. M. Hariono, M. Nawi, Mohd M. S. Wahab, Abdul H. Awang, K. Natural DENV-2 NS2B/NS3 protease inhibitors from Myristica cinnamomea King
description	The NS2B/NS3 protease is crucial for the pathogenesis of the DENV. Therefore, the inhibition of this protease is considered to be the key strategy for the development of new antiviral drugs. In the present study, malabaricones C (3) and E (4), acylphenols from the fruits of Myristica cinnamomea King, have been respectively identified as moderate (27.33 +/- 5.45 mu M) and potent (7.55 +/- 1.64 mu M) DENV-2 NS2B/NS3 protease inhibitors, thus making this the first report on the DENV-2 NS2B/NS3 protease inhibitory activity of acylphenols. Based on the molecular docking studies, compounds 3 and 4 both have pi-pi interactions with Tyr161. While compound 3 has hydrogen bonding interactions with Gly151, Gly153 and Tyr161, compound 4 however, forms hydrogen bonds with Ser135, Asp129, Phe130 and Ile86 instead. The results from the present study suggests that malabaricones C (3) and E (4) could be employed as lead compounds for the development of new dengue antivirals from natural origin.
format	Article
author	Sivasothy, Y. Liew, S. Y. Othman, M. A. Wahab, Abdul S. M. Hariono, M. Nawi, Mohd M. S. Wahab, Abdul H. Awang, K.
author_facet	Sivasothy, Y. Liew, S. Y. Othman, M. A. Wahab, Abdul S. M. Hariono, M. Nawi, Mohd M. S. Wahab, Abdul H. Awang, K.
author_sort	Sivasothy, Y.
title	Natural DENV-2 NS2B/NS3 protease inhibitors from Myristica cinnamomea King
title_short	Natural DENV-2 NS2B/NS3 protease inhibitors from Myristica cinnamomea King
title_full	Natural DENV-2 NS2B/NS3 protease inhibitors from Myristica cinnamomea King
title_fullStr	Natural DENV-2 NS2B/NS3 protease inhibitors from Myristica cinnamomea King
title_full_unstemmed	Natural DENV-2 NS2B/NS3 protease inhibitors from Myristica cinnamomea King
title_sort	natural denv-2 ns2b/ns3 protease inhibitors from myristica cinnamomea king
publisher	Malaysian Soc Parasitology Tropical Medicine
publishDate	2021
url	http://eprints.um.edu.my/34014/
_version_	1738510701177077760
score	13.211869

Natural DENV-2 NS2B/NS3 protease inhibitors from Myristica cinnamomea King

Similar Items