Fragment-based in silico design of SARS-CoV-2 main protease inhibitors
3CLpro is essential for SARS-CoV-2 replication and infection; its inhibition using small molecules is a potential therapeutic strategy. In this study, a comprehensive crystallography-guided fragment-based drug discovery approach was employed to design new inhibitors for SARS-CoV-2 3CLpro. All small...
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Main Authors: | Ahmad, Sarfraz, Mirza, Muhammad Usman, Kee, Lee Yean, Nazir, Mamoona, Abdul Rahman, Noorsaadah, Trant, John F., Abdullah, Iskandar |
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Format: | Article |
Published: |
Wiley
2021
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Subjects: | |
Online Access: | http://eprints.um.edu.my/28707/ |
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