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Biogenic integrated ZnO/Ag nanocomposite: Surface analysis and in vivo practices for the management of type 1 diabetes complications

In this research, a milk thistle seed extract (MTSE)-rich medium was used as a capping and reducing agent for the one-pot biosynthesis of ZnO/Ag (5 wt%) nanostructure. The sample was systematically characterized through various techniques and its strong biomolecule‒metal interface structure was supp...

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Main Authors:	Pouran, Shima Rahim, Bayrami, Abolfazl, Arvanag, Farid Mohammadi, Habibi-Yangjeh, Aziz, Soltani, Reza Darvishi Cheshmeh, Ramesh, Singh, Abdul Raman, Abdul Aziz, Chae, Keun Hwa, Khataee, Alireza, Kang, Hee Kyoung
Format:	Article
Published:	Elsevier 2020
Subjects:	TJ Mechanical engineering and machinery TP Chemical technology
Online Access:	http://eprints.um.edu.my/25360/ https://doi.org/10.1016/j.colsurfb.2020.110878
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spelling	my.um.eprints.253602020-08-14T05:48:03Z http://eprints.um.edu.my/25360/ Biogenic integrated ZnO/Ag nanocomposite: Surface analysis and in vivo practices for the management of type 1 diabetes complications Pouran, Shima Rahim Bayrami, Abolfazl Arvanag, Farid Mohammadi Habibi-Yangjeh, Aziz Soltani, Reza Darvishi Cheshmeh Ramesh, Singh Abdul Raman, Abdul Aziz Chae, Keun Hwa Khataee, Alireza Kang, Hee Kyoung TJ Mechanical engineering and machinery TP Chemical technology In this research, a milk thistle seed extract (MTSE)-rich medium was used as a capping and reducing agent for the one-pot biosynthesis of ZnO/Ag (5 wt%) nanostructure. The sample was systematically characterized through various techniques and its strong biomolecule‒metal interface structure was supported by the results. The efficacy of the derived nanostructure (MTSE/ZnO/Ag) was evaluated in vivo on the basis of its therapeutic effects on the main complications of Type 1 diabetes (hyperglycemia, hyperlipidemia, and insulin deficiency). For this purpose, the changes in the plasma values of fasting blood glucose, total cholesterol, total triglyceride, high-density lipoprotein cholesterol, and insulin in alloxan-diabetic Wistar male rats were compared with those in healthy and untreated diabetic controls after a treatment period of 16 days. The antidiabetic results of MTSE/ZnO/Ag were compared with those obtained from pristine ZnO, MTSE, and insulin therapies. The health conditions of the rats with Type 1 diabetes were significantly enhanced after treatment with MTSE/ZnO/Ag (p < 0.05), which is owing to the enhanced interface structure and participatory functions of the united compartments of MTSE/ZnO/Ag. © 2020 Elsevier 2020 Article PeerReviewed Pouran, Shima Rahim and Bayrami, Abolfazl and Arvanag, Farid Mohammadi and Habibi-Yangjeh, Aziz and Soltani, Reza Darvishi Cheshmeh and Ramesh, Singh and Abdul Raman, Abdul Aziz and Chae, Keun Hwa and Khataee, Alireza and Kang, Hee Kyoung (2020) Biogenic integrated ZnO/Ag nanocomposite: Surface analysis and in vivo practices for the management of type 1 diabetes complications. Colloids and Surfaces B: Biointerfaces, 189. p. 110878. ISSN 0927-7765 https://doi.org/10.1016/j.colsurfb.2020.110878 doi:10.1016/j.colsurfb.2020.110878
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	TJ Mechanical engineering and machinery TP Chemical technology
spellingShingle	TJ Mechanical engineering and machinery TP Chemical technology Pouran, Shima Rahim Bayrami, Abolfazl Arvanag, Farid Mohammadi Habibi-Yangjeh, Aziz Soltani, Reza Darvishi Cheshmeh Ramesh, Singh Abdul Raman, Abdul Aziz Chae, Keun Hwa Khataee, Alireza Kang, Hee Kyoung Biogenic integrated ZnO/Ag nanocomposite: Surface analysis and in vivo practices for the management of type 1 diabetes complications
description	In this research, a milk thistle seed extract (MTSE)-rich medium was used as a capping and reducing agent for the one-pot biosynthesis of ZnO/Ag (5 wt%) nanostructure. The sample was systematically characterized through various techniques and its strong biomolecule‒metal interface structure was supported by the results. The efficacy of the derived nanostructure (MTSE/ZnO/Ag) was evaluated in vivo on the basis of its therapeutic effects on the main complications of Type 1 diabetes (hyperglycemia, hyperlipidemia, and insulin deficiency). For this purpose, the changes in the plasma values of fasting blood glucose, total cholesterol, total triglyceride, high-density lipoprotein cholesterol, and insulin in alloxan-diabetic Wistar male rats were compared with those in healthy and untreated diabetic controls after a treatment period of 16 days. The antidiabetic results of MTSE/ZnO/Ag were compared with those obtained from pristine ZnO, MTSE, and insulin therapies. The health conditions of the rats with Type 1 diabetes were significantly enhanced after treatment with MTSE/ZnO/Ag (p < 0.05), which is owing to the enhanced interface structure and participatory functions of the united compartments of MTSE/ZnO/Ag. © 2020
format	Article
author	Pouran, Shima Rahim Bayrami, Abolfazl Arvanag, Farid Mohammadi Habibi-Yangjeh, Aziz Soltani, Reza Darvishi Cheshmeh Ramesh, Singh Abdul Raman, Abdul Aziz Chae, Keun Hwa Khataee, Alireza Kang, Hee Kyoung
author_facet	Pouran, Shima Rahim Bayrami, Abolfazl Arvanag, Farid Mohammadi Habibi-Yangjeh, Aziz Soltani, Reza Darvishi Cheshmeh Ramesh, Singh Abdul Raman, Abdul Aziz Chae, Keun Hwa Khataee, Alireza Kang, Hee Kyoung
author_sort	Pouran, Shima Rahim
title	Biogenic integrated ZnO/Ag nanocomposite: Surface analysis and in vivo practices for the management of type 1 diabetes complications
title_short	Biogenic integrated ZnO/Ag nanocomposite: Surface analysis and in vivo practices for the management of type 1 diabetes complications
title_full	Biogenic integrated ZnO/Ag nanocomposite: Surface analysis and in vivo practices for the management of type 1 diabetes complications
title_fullStr	Biogenic integrated ZnO/Ag nanocomposite: Surface analysis and in vivo practices for the management of type 1 diabetes complications
title_full_unstemmed	Biogenic integrated ZnO/Ag nanocomposite: Surface analysis and in vivo practices for the management of type 1 diabetes complications
title_sort	biogenic integrated zno/ag nanocomposite: surface analysis and in vivo practices for the management of type 1 diabetes complications
publisher	Elsevier
publishDate	2020
url	http://eprints.um.edu.my/25360/ https://doi.org/10.1016/j.colsurfb.2020.110878
_version_	1680857023525158912
score	13.211869

Biogenic integrated ZnO/Ag nanocomposite: Surface analysis and in vivo practices for the management of type 1 diabetes complications

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