Adverse effect of intraoperative phenylephrine 10%: case report

The case is reported of a patient who suffered severe acute hypertension, cardiac arrhythmia, and myocardial infarction probably as a direct effect of phenylephrine overdose. Instillation of the drops during surgery probably enhanced the systemic absorption of a significant amount of the drug. There...

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Bibliographic Details
Main Author: Lai, Yoon Kee
Format: Article
Published: BMJ Publishing Group 1989
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Online Access:http://eprints.um.edu.my/244/
http://dx.doi.org/10.1136/bjo.73.6.468
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Summary:The case is reported of a patient who suffered severe acute hypertension, cardiac arrhythmia, and myocardial infarction probably as a direct effect of phenylephrine overdose. Instillation of the drops during surgery probably enhanced the systemic absorption of a significant amount of the drug. Therefore it should be used during surgery with caution, especially in elderly patients and those with cardiovascular disease.