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DNA Interactions and Cytotoxicity of the Aryls-Vertexed Zinc(II) Thiosemicarbazone Complex

A new mononuclear zinc complex of N-phenyl-substituted thiophene thiosemicarbazone ligand [Zn(Httsc-N-Ph)2] was synthesized and characterized, and investigated as nuclease mimic. As compared to carboplatin, a much greater activity against HeLa cells is exhibited by [Zn(Httsc-N-Ph)2] which binds to D...

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Main Authors: Vikneswaran, R., Eltayeb, N.E., Ramesh, S., Yahya, R.
Format: Article
Published: Chemical Society of Japan 2015
Subjects:
Q Science (General)
QC Physics
QD Chemistry
Online Access:http://eprints.um.edu.my/19493/
http://dx.doi.org/10.1246/bcsj.20150084
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spelling my.um.eprints.194932018-10-01T03:25:18Z http://eprints.um.edu.my/19493/ DNA Interactions and Cytotoxicity of the Aryls-Vertexed Zinc(II) Thiosemicarbazone Complex Vikneswaran, R. Eltayeb, N.E. Ramesh, S. Yahya, R. Q Science (General) QC Physics QD Chemistry A new mononuclear zinc complex of N-phenyl-substituted thiophene thiosemicarbazone ligand [Zn(Httsc-N-Ph)2] was synthesized and characterized, and investigated as nuclease mimic. As compared to carboplatin, a much greater activity against HeLa cells is exhibited by [Zn(Httsc-N-Ph)2] which binds to DNA through an intercalation mechanism. Chemical Society of Japan 2015 Article PeerReviewed Vikneswaran, R. and Eltayeb, N.E. and Ramesh, S. and Yahya, R. (2015) DNA Interactions and Cytotoxicity of the Aryls-Vertexed Zinc(II) Thiosemicarbazone Complex. Bulletin of the Chemical Society of Japan, 88 (8). pp. 1156-1158. ISSN 0009-2673 http://dx.doi.org/10.1246/bcsj.20150084 doi:10.1246/bcsj.20150084
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
QC Physics
QD Chemistry
spellingShingle Q Science (General)
QC Physics
QD Chemistry
Vikneswaran, R.
Eltayeb, N.E.
Ramesh, S.
Yahya, R.
DNA Interactions and Cytotoxicity of the Aryls-Vertexed Zinc(II) Thiosemicarbazone Complex
description A new mononuclear zinc complex of N-phenyl-substituted thiophene thiosemicarbazone ligand [Zn(Httsc-N-Ph)2] was synthesized and characterized, and investigated as nuclease mimic. As compared to carboplatin, a much greater activity against HeLa cells is exhibited by [Zn(Httsc-N-Ph)2] which binds to DNA through an intercalation mechanism.
format Article
author Vikneswaran, R.
Eltayeb, N.E.
Ramesh, S.
Yahya, R.
author_facet Vikneswaran, R.
Eltayeb, N.E.
Ramesh, S.
Yahya, R.
author_sort Vikneswaran, R.
title DNA Interactions and Cytotoxicity of the Aryls-Vertexed Zinc(II) Thiosemicarbazone Complex
title_short DNA Interactions and Cytotoxicity of the Aryls-Vertexed Zinc(II) Thiosemicarbazone Complex
title_full DNA Interactions and Cytotoxicity of the Aryls-Vertexed Zinc(II) Thiosemicarbazone Complex
title_fullStr DNA Interactions and Cytotoxicity of the Aryls-Vertexed Zinc(II) Thiosemicarbazone Complex
title_full_unstemmed DNA Interactions and Cytotoxicity of the Aryls-Vertexed Zinc(II) Thiosemicarbazone Complex
title_sort dna interactions and cytotoxicity of the aryls-vertexed zinc(ii) thiosemicarbazone complex
publisher Chemical Society of Japan
publishDate 2015
url http://eprints.um.edu.my/19493/
http://dx.doi.org/10.1246/bcsj.20150084
_version_ 1643691004667101184
score 13.211869

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