DNA Interactions and Cytotoxicity of the Aryls-Vertexed Zinc(II) Thiosemicarbazone Complex
A new mononuclear zinc complex of N-phenyl-substituted thiophene thiosemicarbazone ligand [Zn(Httsc-N-Ph)2] was synthesized and characterized, and investigated as nuclease mimic. As compared to carboplatin, a much greater activity against HeLa cells is exhibited by [Zn(Httsc-N-Ph)2] which binds to D...
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| Main Authors: | , , , |
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| Format: | Article |
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Chemical Society of Japan
2015
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/19493/ http://dx.doi.org/10.1246/bcsj.20150084 |
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| Summary: | A new mononuclear zinc complex of N-phenyl-substituted thiophene thiosemicarbazone ligand [Zn(Httsc-N-Ph)2] was synthesized and characterized, and investigated as nuclease mimic. As compared to carboplatin, a much greater activity against HeLa cells is exhibited by [Zn(Httsc-N-Ph)2] which binds to DNA through an intercalation mechanism. |
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