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Transcriptome profiling of monocytes from XLA patients revealed the innate immune function dysregulation due to the BTK gene expression deficiency

X-linked agammaglobulinemia (XLA) is a rare genetic disorder, caused by mutations in BTK (Bruton's Tyrosine Kinase) gene. Deep high-throughput RNA sequencing (RNA-Seq) approach was utilized to explore the possible differences in transcriptome profiles of primary monocytes in XLA patients compar...

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Bibliographic Details
Main Authors: Mirsafian, H., Ripen, A.M., Leong, W.M., Chear, C.T., Mohamad, S.B., Merican, A.F.
Format: Article
Language:English
Published: Nature Publishing Group 2017
Subjects:
Q Science (General)
QH Natural history
Online Access:http://eprints.um.edu.my/18995/1/Transcriptome_profiling_of_monocytes_from_XLA_patients_revealed_the_innate_immune_function_dysregulation_due_to_the_BTK_gene_expression_deficiency.pdf
http://eprints.um.edu.my/18995/
http://dx.doi.org/10.1038/s41598-017-06342-5
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http://eprints.um.edu.my/18995/1/Transcriptome_profiling_of_monocytes_from_XLA_patients_revealed_the_innate_immune_function_dysregulation_due_to_the_BTK_gene_expression_deficiency.pdf
http://eprints.um.edu.my/18995/
http://dx.doi.org/10.1038/s41598-017-06342-5

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