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The association between orthostatic hypotension and medication use in the British women's heart and health study

Design: cross-sectional analysis using data from the British Women's Heart and Health Study. Setting: general practices in 23 towns in the UK. Participants: 3,775 women aged 60-80 years from 1999 to 2001. Main outcome measure: orthostatic hypotension-drop of >= 20 mmHg in systolic and/or a d...

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Main Authors: Kamaruzzaman, S., Watt, H., Carson, C., Ebrahim, S.
Format: Article
Published: Oxford University Press 2010
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/15315/
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spelling my.um.eprints.153152015-12-28T02:02:29Z http://eprints.um.edu.my/15315/ The association between orthostatic hypotension and medication use in the British women's heart and health study Kamaruzzaman, S. Watt, H. Carson, C. Ebrahim, S. R Medicine Design: cross-sectional analysis using data from the British Women's Heart and Health Study. Setting: general practices in 23 towns in the UK. Participants: 3,775 women aged 60-80 years from 1999 to 2001. Main outcome measure: orthostatic hypotension-drop of >= 20 mmHg in systolic and/or a drop of >= 10 mmHg in diastolic blood pressure on standing. Results: prevalence of OH was 28% (95% confidence interval [CI] 26.6, 29.4), which increased with age and hypertension. Regardless of treatment status or diagnosed hypertension, raised blood pressure was strongly associated with OH (P < 0.001). OH was strongly associated with number of antihypertensives taken (none vs three or more: odds ratio [OR] 2.24, 95% CI 1.47-3.40, P < 0.001); the association was slightly attenuated after allowing for age and co-morbidities (OR 1.99; 95% CI 1.30, 3.05; P = 0.003). Women with multiple co-morbidities had markedly increased odds of OH independent of age, number and type of medications taken (none vs four or more diagnoses: OR 2.28, 95% CI 1.58-3.30, P = 0.005). Conclusion: uncontrolled hypertension, use of three or more antihypertensives and multiple co-morbidities are predictors of OH in older women. Detection or monitoring of OH in these groups may prevent women from suffering its adverse consequences. Oxford University Press 2010 Article PeerReviewed Kamaruzzaman, S. and Watt, H. and Carson, C. and Ebrahim, S. (2010) The association between orthostatic hypotension and medication use in the British women's heart and health study. Age and Ageing, 39 (1). pp. 51-56.
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Kamaruzzaman, S.
Watt, H.
Carson, C.
Ebrahim, S.
The association between orthostatic hypotension and medication use in the British women's heart and health study
description Design: cross-sectional analysis using data from the British Women's Heart and Health Study. Setting: general practices in 23 towns in the UK. Participants: 3,775 women aged 60-80 years from 1999 to 2001. Main outcome measure: orthostatic hypotension-drop of >= 20 mmHg in systolic and/or a drop of >= 10 mmHg in diastolic blood pressure on standing. Results: prevalence of OH was 28% (95% confidence interval [CI] 26.6, 29.4), which increased with age and hypertension. Regardless of treatment status or diagnosed hypertension, raised blood pressure was strongly associated with OH (P < 0.001). OH was strongly associated with number of antihypertensives taken (none vs three or more: odds ratio [OR] 2.24, 95% CI 1.47-3.40, P < 0.001); the association was slightly attenuated after allowing for age and co-morbidities (OR 1.99; 95% CI 1.30, 3.05; P = 0.003). Women with multiple co-morbidities had markedly increased odds of OH independent of age, number and type of medications taken (none vs four or more diagnoses: OR 2.28, 95% CI 1.58-3.30, P = 0.005). Conclusion: uncontrolled hypertension, use of three or more antihypertensives and multiple co-morbidities are predictors of OH in older women. Detection or monitoring of OH in these groups may prevent women from suffering its adverse consequences.
format Article
author Kamaruzzaman, S.
Watt, H.
Carson, C.
Ebrahim, S.
author_facet Kamaruzzaman, S.
Watt, H.
Carson, C.
Ebrahim, S.
author_sort Kamaruzzaman, S.
title The association between orthostatic hypotension and medication use in the British women's heart and health study
title_short The association between orthostatic hypotension and medication use in the British women's heart and health study
title_full The association between orthostatic hypotension and medication use in the British women's heart and health study
title_fullStr The association between orthostatic hypotension and medication use in the British women's heart and health study
title_full_unstemmed The association between orthostatic hypotension and medication use in the British women's heart and health study
title_sort association between orthostatic hypotension and medication use in the british women's heart and health study
publisher Oxford University Press
publishDate 2010
url http://eprints.um.edu.my/15315/
_version_ 1643690027925897216
score 13.211869

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