The association between orthostatic hypotension and medication use in the British women's heart and health study
Design: cross-sectional analysis using data from the British Women's Heart and Health Study. Setting: general practices in 23 towns in the UK. Participants: 3,775 women aged 60-80 years from 1999 to 2001. Main outcome measure: orthostatic hypotension-drop of >= 20 mmHg in systolic and/or a d...
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| Main Authors: | , , , |
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| Format: | Article |
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Oxford University Press
2010
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| Online Access: | http://eprints.um.edu.my/15315/ |
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| Summary: | Design: cross-sectional analysis using data from the British Women's Heart and Health Study. Setting: general practices in 23 towns in the UK. Participants: 3,775 women aged 60-80 years from 1999 to 2001. Main outcome measure: orthostatic hypotension-drop of >= 20 mmHg in systolic and/or a drop of >= 10 mmHg in diastolic blood pressure on standing. Results: prevalence of OH was 28% (95% confidence interval [CI] 26.6, 29.4), which increased with age and hypertension. Regardless of treatment status or diagnosed hypertension, raised blood pressure was strongly associated with OH (P < 0.001). OH was strongly associated with number of antihypertensives taken (none vs three or more: odds ratio [OR] 2.24, 95% CI 1.47-3.40, P < 0.001); the association was slightly attenuated after allowing for age and co-morbidities (OR 1.99; 95% CI 1.30, 3.05; P = 0.003). Women with multiple co-morbidities had markedly increased odds of OH independent of age, number and type of medications taken (none vs four or more diagnoses: OR 2.28, 95% CI 1.58-3.30, P = 0.005). Conclusion: uncontrolled hypertension, use of three or more antihypertensives and multiple co-morbidities are predictors of OH in older women. Detection or monitoring of OH in these groups may prevent women from suffering its adverse consequences. |
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