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Viscosity modifying properties of citrate compounds / Syakinah Mohd Shukri

AIM: This study reported the effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose (HPMC) solution. METHOD: The HPMC solution, with or without the incorporation of additives, was subjected to viscosity test using a U-tube viscometer at 30°C. Selected samples of...

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Main Author: Mohd Shukri, Syakinah
Format: Thesis
Language:English
Published: 2006
Subjects:
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
Online Access:https://ir.uitm.edu.my/id/eprint/99059/1/99059.PDF
https://ir.uitm.edu.my/id/eprint/99059/
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spelling my.uitm.ir.990592024-07-24T03:07:37Z https://ir.uitm.edu.my/id/eprint/99059/ Viscosity modifying properties of citrate compounds / Syakinah Mohd Shukri Mohd Shukri, Syakinah RM Therapeutics. Pharmacology RS Pharmacy and materia medica AIM: This study reported the effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose (HPMC) solution. METHOD: The HPMC solution, with or without the incorporation of additives, was subjected to viscosity test using a U-tube viscometer at 30°C. Selected samples of test solutions were subjected to Fourier Transform Infrared spectroscopy (FTIR) analysis. RESULTS: The viscosity of HPMC solutions was reduced when appropriate amounts of citric acid, triacetin, triethyl citrate and trisodium citrate were added. Using 0.5% (w/w) HPMC solution, small molecular weight additive such as citric acid demonstrated the best viscosity lowering effect when an appropriate amount of citric acid was added. Using I% (w/w) HPMC solution, trisodium citrate demonstrated the best viscosity lowering effect when an appropriate amount of trisodium citrate was added. FTIR analysis indicated that the viscosity profile of HPMC solution could be mediated through the interaction of additives with HPMC via 0-H or non 0-H functional groups of the polymer. CONCLUSION: Citric acid, triacetin, triethyl citrate and trisodium citrate exhibited viscosity modifying properties in HPMC solution. 2006 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/99059/1/99059.PDF Viscosity modifying properties of citrate compounds / Syakinah Mohd Shukri. (2006) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
spellingShingle RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
Mohd Shukri, Syakinah
Viscosity modifying properties of citrate compounds / Syakinah Mohd Shukri
description AIM: This study reported the effects of citrate based additives on the viscosity profile of hydroxypropylmethylcellulose (HPMC) solution. METHOD: The HPMC solution, with or without the incorporation of additives, was subjected to viscosity test using a U-tube viscometer at 30°C. Selected samples of test solutions were subjected to Fourier Transform Infrared spectroscopy (FTIR) analysis. RESULTS: The viscosity of HPMC solutions was reduced when appropriate amounts of citric acid, triacetin, triethyl citrate and trisodium citrate were added. Using 0.5% (w/w) HPMC solution, small molecular weight additive such as citric acid demonstrated the best viscosity lowering effect when an appropriate amount of citric acid was added. Using I% (w/w) HPMC solution, trisodium citrate demonstrated the best viscosity lowering effect when an appropriate amount of trisodium citrate was added. FTIR analysis indicated that the viscosity profile of HPMC solution could be mediated through the interaction of additives with HPMC via 0-H or non 0-H functional groups of the polymer. CONCLUSION: Citric acid, triacetin, triethyl citrate and trisodium citrate exhibited viscosity modifying properties in HPMC solution.
format Thesis
author Mohd Shukri, Syakinah
author_facet Mohd Shukri, Syakinah
author_sort Mohd Shukri, Syakinah
title Viscosity modifying properties of citrate compounds / Syakinah Mohd Shukri
title_short Viscosity modifying properties of citrate compounds / Syakinah Mohd Shukri
title_full Viscosity modifying properties of citrate compounds / Syakinah Mohd Shukri
title_fullStr Viscosity modifying properties of citrate compounds / Syakinah Mohd Shukri
title_full_unstemmed Viscosity modifying properties of citrate compounds / Syakinah Mohd Shukri
title_sort viscosity modifying properties of citrate compounds / syakinah mohd shukri
publishDate 2006
url https://ir.uitm.edu.my/id/eprint/99059/1/99059.PDF
https://ir.uitm.edu.my/id/eprint/99059/
_version_ 1806422136204558336
score 13.250246

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