Design, synthesis and determination of biological activities of stilbene analogue attached to zinc (ii)-cyclen complex / Nafiza Mohd Ismail
The significance of this research is to design, synthesis and determination of biological activities of resveratrol (stilbene) analogue attached to Zn2+-cyclen complex. Three established reactions had been used in order to accomplish the research. First, the 3,5- dimethoxybenzaldehyde was utilizes a...
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| Format: | Thesis |
| Language: | English |
| Published: |
2005
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| Subjects: | |
| Online Access: | https://ir.uitm.edu.my/id/eprint/98655/1/98655.PDF https://ir.uitm.edu.my/id/eprint/98655/ |
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| Summary: | The significance of this research is to design, synthesis and determination of biological activities of resveratrol (stilbene) analogue attached to Zn2+-cyclen complex. Three established reactions had been used in order to accomplish the research. First, the 3,5- dimethoxybenzaldehyde was utilizes as a starting material of the Wittig reaction. Subsequently, protection of the 4-iodophenol using TBDMS-C1 to yield 4-iodo-tert- butyldimethylsilylphenylether. Product of the Wittig reaction and 4-iodo-/er/- butyldimethylsilylphenylether were then use to synthesize the stilbene analogue. The synthesized compounds were then, purified by chromatographic techniques and sent for 'H-NMR and UV characterization. The outcomes of this research did not make the grade, and the research was postponed due time constraint. |
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