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Association of smoking and severity of Covid-19 infection among 5,889 patients in Malaysia: a multi-center observational study

Objective: This study aims to investigate the association between smoking and the severity of COVID-19 infection during the initial wave of this pandemic in Malaysia. Methods: This is a multi-center observational study using secondary hospital data collected retrospectively from February 1, 2020,...

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Main Authors: Ismail, Norliana, Hassan, Noraryana, Abd Hamid, Muhammad Hairul Nizam, Yusoff, Ummi Nadiah, Khamal, Noor Raihan, Omar, Mohd Azahadi, Xin, Ci Wong, Pathmanathan, Mohan Dass, Mohd Zin, Shahanizan, Muhammad Zin, Faizah, Nik Mohamed, Mohamad Haniki, Mohd Nor, Norashidah
Format: Article
Language:English
English
Published: Elsevier B.V. 2022
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/96826/2/Association%20of%20smoking%20and%20severity%20of%20Covid-19_SCOPUS.pdf
http://irep.iium.edu.my/96826/13/96826_Association%20of%20smoking%20and%20severity%20of%20Covid-19.pdf
http://irep.iium.edu.my/96826/
https://www.ijidonline.com/action/showPdf?pii=S1201-9712%2822%2900012-1
https://doi.org/10.1016/j.ijid.2022.01.011
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spelling my.iium.irep.968262022-03-25T00:46:36Z http://irep.iium.edu.my/96826/ Association of smoking and severity of Covid-19 infection among 5,889 patients in Malaysia: a multi-center observational study Ismail, Norliana Hassan, Noraryana Abd Hamid, Muhammad Hairul Nizam Yusoff, Ummi Nadiah Khamal, Noor Raihan Omar, Mohd Azahadi Xin, Ci Wong Pathmanathan, Mohan Dass Mohd Zin, Shahanizan Muhammad Zin, Faizah Nik Mohamed, Mohamad Haniki Mohd Nor, Norashidah R Medicine (General) Objective: This study aims to investigate the association between smoking and the severity of COVID-19 infection during the initial wave of this pandemic in Malaysia. Methods: This is a multi-center observational study using secondary hospital data collected retrospectively from February 1, 2020, until May 30, 2020. Clinical records of all real-time polymerase chain reaction (RT-PCR)-confirmed COVID-19 cases with smoking status, co-morbidities, clinical features, and disease management were retrieved. Severity was assessed by the presence of complications and outcomes of COVID-19 infection. Logistic regression was used to determine the association between COVID-19 disease severity and smoking status. Results: A total of 5,889 COVID-19 cases were included in the analysis. Ever smokers had a higher risk of having COVID-19 complications, such as acute respiratory distress syndrome (odds ratio [OR] 1.69; 95% confidence interval [CI] 1.09-2.55), renal injury (OR 1.55; 95% CI 1.10-2.14), and acute liver injury (OR 1.33; 95% CI 1.01-1.74), compared with never smokers. However, in terms of disease outcomes, there were no differences between the two groups. Conclusion: Although no significant association was found in terms of disease outcomes, smoking is associated with a higher risk of having complications owing to COVID-19 infection. Elsevier B.V. 2022-01-05 Article PeerReviewed application/pdf en http://irep.iium.edu.my/96826/2/Association%20of%20smoking%20and%20severity%20of%20Covid-19_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/96826/13/96826_Association%20of%20smoking%20and%20severity%20of%20Covid-19.pdf Ismail, Norliana and Hassan, Noraryana and Abd Hamid, Muhammad Hairul Nizam and Yusoff, Ummi Nadiah and Khamal, Noor Raihan and Omar, Mohd Azahadi and Xin, Ci Wong and Pathmanathan, Mohan Dass and Mohd Zin, Shahanizan and Muhammad Zin, Faizah and Nik Mohamed, Mohamad Haniki and Mohd Nor, Norashidah (2022) Association of smoking and severity of Covid-19 infection among 5,889 patients in Malaysia: a multi-center observational study. International Journal of Infectious Diseases, 116. pp. 189-196. ISSN 1201-9712 https://www.ijidonline.com/action/showPdf?pii=S1201-9712%2822%2900012-1 https://doi.org/10.1016/j.ijid.2022.01.011
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic R Medicine (General)
spellingShingle R Medicine (General)
Ismail, Norliana
Hassan, Noraryana
Abd Hamid, Muhammad Hairul Nizam
Yusoff, Ummi Nadiah
Khamal, Noor Raihan
Omar, Mohd Azahadi
Xin, Ci Wong
Pathmanathan, Mohan Dass
Mohd Zin, Shahanizan
Muhammad Zin, Faizah
Nik Mohamed, Mohamad Haniki
Mohd Nor, Norashidah
Association of smoking and severity of Covid-19 infection among 5,889 patients in Malaysia: a multi-center observational study
description Objective: This study aims to investigate the association between smoking and the severity of COVID-19 infection during the initial wave of this pandemic in Malaysia. Methods: This is a multi-center observational study using secondary hospital data collected retrospectively from February 1, 2020, until May 30, 2020. Clinical records of all real-time polymerase chain reaction (RT-PCR)-confirmed COVID-19 cases with smoking status, co-morbidities, clinical features, and disease management were retrieved. Severity was assessed by the presence of complications and outcomes of COVID-19 infection. Logistic regression was used to determine the association between COVID-19 disease severity and smoking status. Results: A total of 5,889 COVID-19 cases were included in the analysis. Ever smokers had a higher risk of having COVID-19 complications, such as acute respiratory distress syndrome (odds ratio [OR] 1.69; 95% confidence interval [CI] 1.09-2.55), renal injury (OR 1.55; 95% CI 1.10-2.14), and acute liver injury (OR 1.33; 95% CI 1.01-1.74), compared with never smokers. However, in terms of disease outcomes, there were no differences between the two groups. Conclusion: Although no significant association was found in terms of disease outcomes, smoking is associated with a higher risk of having complications owing to COVID-19 infection.
format Article
author Ismail, Norliana
Hassan, Noraryana
Abd Hamid, Muhammad Hairul Nizam
Yusoff, Ummi Nadiah
Khamal, Noor Raihan
Omar, Mohd Azahadi
Xin, Ci Wong
Pathmanathan, Mohan Dass
Mohd Zin, Shahanizan
Muhammad Zin, Faizah
Nik Mohamed, Mohamad Haniki
Mohd Nor, Norashidah
author_facet Ismail, Norliana
Hassan, Noraryana
Abd Hamid, Muhammad Hairul Nizam
Yusoff, Ummi Nadiah
Khamal, Noor Raihan
Omar, Mohd Azahadi
Xin, Ci Wong
Pathmanathan, Mohan Dass
Mohd Zin, Shahanizan
Muhammad Zin, Faizah
Nik Mohamed, Mohamad Haniki
Mohd Nor, Norashidah
author_sort Ismail, Norliana
title Association of smoking and severity of Covid-19 infection among 5,889 patients in Malaysia: a multi-center observational study
title_short Association of smoking and severity of Covid-19 infection among 5,889 patients in Malaysia: a multi-center observational study
title_full Association of smoking and severity of Covid-19 infection among 5,889 patients in Malaysia: a multi-center observational study
title_fullStr Association of smoking and severity of Covid-19 infection among 5,889 patients in Malaysia: a multi-center observational study
title_full_unstemmed Association of smoking and severity of Covid-19 infection among 5,889 patients in Malaysia: a multi-center observational study
title_sort association of smoking and severity of covid-19 infection among 5,889 patients in malaysia: a multi-center observational study
publisher Elsevier B.V.
publishDate 2022
url http://irep.iium.edu.my/96826/2/Association%20of%20smoking%20and%20severity%20of%20Covid-19_SCOPUS.pdf
http://irep.iium.edu.my/96826/13/96826_Association%20of%20smoking%20and%20severity%20of%20Covid-19.pdf
http://irep.iium.edu.my/96826/
https://www.ijidonline.com/action/showPdf?pii=S1201-9712%2822%2900012-1
https://doi.org/10.1016/j.ijid.2022.01.011
_version_ 1729702915782737920
score 13.211869

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