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Electro-hydrodynamic assisted synthesis of lecithin-stabilized peppermint oil-loaded alginate microbeads for intestinal drug delivery

Peppermint oil (PO) is the most prominent oil using in pharmaceutical formulations with its significant therapeutic value. In this sense, this oil is attracting considerable attention from the scientific community due to its traditional therapeutic claim, biological and pharmacological potential i...

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Main Authors: Abdul Kalam, Azad, Doolaanea, Abd Almonem, Sinan Mohammed Abdullah, Al-Mahmood, John F., Kennedy, Chatterjee, Bappaditya, Bera, Hriday
Format: Article
Language:English
English
Published: Elsevier 2021
Subjects:
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/90814/7/90814_Electro-hydrodynamic%20assisted%20synthesis%20of%20lecithin-stabilized%20peppermint_SCOPUS.pdf
http://irep.iium.edu.my/90814/8/90814_Electro-hydrodynamic%20assisted%20synthesis%20of%20lecithin-stabilized%20peppermint.pdf
http://irep.iium.edu.my/90814/
https://www.sciencedirect.com/science/article/abs/pii/S0141813021014562
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spelling my.iium.irep.908142021-07-14T06:27:10Z http://irep.iium.edu.my/90814/ Electro-hydrodynamic assisted synthesis of lecithin-stabilized peppermint oil-loaded alginate microbeads for intestinal drug delivery Abdul Kalam, Azad Doolaanea, Abd Almonem Sinan Mohammed Abdullah, Al-Mahmood John F., Kennedy Chatterjee, Bappaditya Bera, Hriday RS Pharmacy and materia medica Peppermint oil (PO) is the most prominent oil using in pharmaceutical formulations with its significant therapeutic value. In this sense, this oil is attracting considerable attention from the scientific community due to its traditional therapeutic claim, biological and pharmacological potential in recent research. An organic solventfree and environment-friendly electrohydrodynamic assisted (EHDA) technique was employed to prepared POloaded alginate microbeads. The current study deals with the development, optimization, in vitro characterization, in vivo gastrointestinal tract drug distribution and ex-vivo mucoadhesive properties, antioxidant, and antiinflammatory effects of PO-loaded alginate microbeads. The optimization results indicated the voltage and flow rate have a significant influence on microbeads size and sphericity factor and encapsulation efficiency. All these optimized microbeads showed a better drug release profile in simulated intestinal fluid (pH 6.8) at 2 h. However, a minor release was found in acidic media (pH 1.2) at 2 h. The optimized formulation showed excellent mucoadhesive properties in ex-vivo and good swelling characterization in intestine media. The microbeads were found to be well distributed in various parts of the intestine in in vivo study. PO-loaded alginate microbeads similarly showed potential antioxidant effects with drug release. The formulation exhibited possible improvement of irritable bowel syndrome (IBS) in MO-induced rats. It significantly suppressed proinflammatory cytokines, i.e., interleukin- IL-1β, and upregulated anti-inflammatory cytokine expression, i.e., IL-10. It would be a promising approach for targeted drug release after oral administration and could be considered an antiinflammatory therapeutic strategy for treating IBS. Elsevier 2021-07-05 Article PeerReviewed application/pdf en http://irep.iium.edu.my/90814/7/90814_Electro-hydrodynamic%20assisted%20synthesis%20of%20lecithin-stabilized%20peppermint_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/90814/8/90814_Electro-hydrodynamic%20assisted%20synthesis%20of%20lecithin-stabilized%20peppermint.pdf Abdul Kalam, Azad and Doolaanea, Abd Almonem and Sinan Mohammed Abdullah, Al-Mahmood and John F., Kennedy and Chatterjee, Bappaditya and Bera, Hriday (2021) Electro-hydrodynamic assisted synthesis of lecithin-stabilized peppermint oil-loaded alginate microbeads for intestinal drug delivery. International Journal of Biological Macromolecules, 185. pp. 861-875. ISSN 0141-8130 https://www.sciencedirect.com/science/article/abs/pii/S0141813021014562 10.1016/j.ijbiomac.2021.07.019
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Abdul Kalam, Azad
Doolaanea, Abd Almonem
Sinan Mohammed Abdullah, Al-Mahmood
John F., Kennedy
Chatterjee, Bappaditya
Bera, Hriday
Electro-hydrodynamic assisted synthesis of lecithin-stabilized peppermint oil-loaded alginate microbeads for intestinal drug delivery
description Peppermint oil (PO) is the most prominent oil using in pharmaceutical formulations with its significant therapeutic value. In this sense, this oil is attracting considerable attention from the scientific community due to its traditional therapeutic claim, biological and pharmacological potential in recent research. An organic solventfree and environment-friendly electrohydrodynamic assisted (EHDA) technique was employed to prepared POloaded alginate microbeads. The current study deals with the development, optimization, in vitro characterization, in vivo gastrointestinal tract drug distribution and ex-vivo mucoadhesive properties, antioxidant, and antiinflammatory effects of PO-loaded alginate microbeads. The optimization results indicated the voltage and flow rate have a significant influence on microbeads size and sphericity factor and encapsulation efficiency. All these optimized microbeads showed a better drug release profile in simulated intestinal fluid (pH 6.8) at 2 h. However, a minor release was found in acidic media (pH 1.2) at 2 h. The optimized formulation showed excellent mucoadhesive properties in ex-vivo and good swelling characterization in intestine media. The microbeads were found to be well distributed in various parts of the intestine in in vivo study. PO-loaded alginate microbeads similarly showed potential antioxidant effects with drug release. The formulation exhibited possible improvement of irritable bowel syndrome (IBS) in MO-induced rats. It significantly suppressed proinflammatory cytokines, i.e., interleukin- IL-1β, and upregulated anti-inflammatory cytokine expression, i.e., IL-10. It would be a promising approach for targeted drug release after oral administration and could be considered an antiinflammatory therapeutic strategy for treating IBS.
format Article
author Abdul Kalam, Azad
Doolaanea, Abd Almonem
Sinan Mohammed Abdullah, Al-Mahmood
John F., Kennedy
Chatterjee, Bappaditya
Bera, Hriday
author_facet Abdul Kalam, Azad
Doolaanea, Abd Almonem
Sinan Mohammed Abdullah, Al-Mahmood
John F., Kennedy
Chatterjee, Bappaditya
Bera, Hriday
author_sort Abdul Kalam, Azad
title Electro-hydrodynamic assisted synthesis of lecithin-stabilized peppermint oil-loaded alginate microbeads for intestinal drug delivery
title_short Electro-hydrodynamic assisted synthesis of lecithin-stabilized peppermint oil-loaded alginate microbeads for intestinal drug delivery
title_full Electro-hydrodynamic assisted synthesis of lecithin-stabilized peppermint oil-loaded alginate microbeads for intestinal drug delivery
title_fullStr Electro-hydrodynamic assisted synthesis of lecithin-stabilized peppermint oil-loaded alginate microbeads for intestinal drug delivery
title_full_unstemmed Electro-hydrodynamic assisted synthesis of lecithin-stabilized peppermint oil-loaded alginate microbeads for intestinal drug delivery
title_sort electro-hydrodynamic assisted synthesis of lecithin-stabilized peppermint oil-loaded alginate microbeads for intestinal drug delivery
publisher Elsevier
publishDate 2021
url http://irep.iium.edu.my/90814/7/90814_Electro-hydrodynamic%20assisted%20synthesis%20of%20lecithin-stabilized%20peppermint_SCOPUS.pdf
http://irep.iium.edu.my/90814/8/90814_Electro-hydrodynamic%20assisted%20synthesis%20of%20lecithin-stabilized%20peppermint.pdf
http://irep.iium.edu.my/90814/
https://www.sciencedirect.com/science/article/abs/pii/S0141813021014562
_version_ 1706956591080669184
score 13.211869

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