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Lyophilized amorphous dispersion of telmisartan in a combined carrier–alkalizer system: formulation development and in vivo study

Telmisartan suffers from low oral bioavailability due to its poor water solubility. The research work presents a formulation of solid dispersed (SD) telmisartan formulation as a ternary mixture of a drug, a polymeric carrier (poly(vinylpyrrolidone) (PVP) K30), and an alkalizer (Na2CO3). The preparat...

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Bibliographic Details
Main Authors: Aljapairai, Khater Ahmed Saeed, Alkhalidi, Hala M., Mahmood, Syed, Almurisi, Samah Hamed, Doolaanea, Abd Almonem, Al-Sindi, Taha A., Chatterjee, Bappaditya
Format: Article
Language:English
English
Published: American Chemical Society 2020
Subjects:
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/88239/7/88239_Lyophilized%20amorphous%20dispersion.pdf
http://irep.iium.edu.my/88239/8/88239_Lyophilized%20amorphous%20dispersion%20of%20telmisartan%20in%20a%20combined%20_Scopus.pdf
http://irep.iium.edu.my/88239/
https://pubs.acs.org/doi/10.1021/acsomega.0c04588
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http://irep.iium.edu.my/88239/7/88239_Lyophilized%20amorphous%20dispersion.pdf
http://irep.iium.edu.my/88239/8/88239_Lyophilized%20amorphous%20dispersion%20of%20telmisartan%20in%20a%20combined%20_Scopus.pdf
http://irep.iium.edu.my/88239/
https://pubs.acs.org/doi/10.1021/acsomega.0c04588

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