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Alkaloids from Popowia perakensis and their dipeptidyl peptidase IV(DPP IV) inhibitors

A study on the alkaloidal composition on the Malaysian Annonaceae species, i.e Popowia perakensis King has been carried out. Barks of Popowia perakensis were extracted with hexane, dichloromethane and methanol, respectively. Dichloromethane extract further underwent the acid base treatment to give...

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Main Authors: Syed Abdul Azziz, Saripah Salbiah, Mukhtar, Mat Ropi, A.Hadi, A.Hamid, Mhd Bakri, Yuhanis, Abdulaimi, Ahmed Kareem Obaid, Awang, Khalijah, Hashim, Yumi Zuhanis Has-Yun
Format: Article
Language:English
Published: Research Journal of Pharmacy and Technology 2019
Subjects:
Q Science (General)
Online Access:http://irep.iium.edu.my/77248/1/77248_%20Alkaloids%20from%20Popowia%20perakensis.pdf
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spelling my.iium.irep.772482020-01-23T07:15:27Z http://irep.iium.edu.my/77248/ Alkaloids from Popowia perakensis and their dipeptidyl peptidase IV(DPP IV) inhibitors Syed Abdul Azziz, Saripah Salbiah Mukhtar, Mat Ropi A.Hadi, A.Hamid Mhd Bakri, Yuhanis Abdulaimi, Ahmed Kareem Obaid Awang, Khalijah Hashim, Yumi Zuhanis Has-Yun Q Science (General) A study on the alkaloidal composition on the Malaysian Annonaceae species, i.e Popowia perakensis King has been carried out. Barks of Popowia perakensis were extracted with hexane, dichloromethane and methanol, respectively. Dichloromethane extract further underwent the acid base treatment to give the alkaloidal crude extract. Isolation of compounds was carried out using various chromatography techniques including column chromatography and thin layer chromatography. Spectroscopic methods notably 1H, 13C NMR, IR, UV and GCMS spectroscopy were utilized to identify pure compounds in addition to comparison of reported data. Two azaanthraquinones alkaloids namely cleistopholine 1 and 6-methoxycleistopholine 2 together with simple isoquinolone alkaloid, N-methylcorydaldine 3 had been isolated. All three alkaloids are known but they were isolated for the first time from this species. Cleistopholine 1 was tested for Dipeptidyl peptidase IV (DPP IV) inhibition to investigate its potential antidiabetic activities. Results revealed that this compound showed quite weak (6.26 %) inhibitory activities as compared to the positive control, Diprotin A (81.46 %). The quantity of the other two compounds was insufficient for the screening purposes. Research Journal of Pharmacy and Technology 2019 Article PeerReviewed application/pdf en http://irep.iium.edu.my/77248/1/77248_%20Alkaloids%20from%20Popowia%20perakensis.pdf Syed Abdul Azziz, Saripah Salbiah and Mukhtar, Mat Ropi and A.Hadi, A.Hamid and Mhd Bakri, Yuhanis and Abdulaimi, Ahmed Kareem Obaid and Awang, Khalijah and Hashim, Yumi Zuhanis Has-Yun (2019) Alkaloids from Popowia perakensis and their dipeptidyl peptidase IV(DPP IV) inhibitors. Research Journal of Pharmacy and Technology, 12 (1). pp. 113-116. ISSN 0974-3618 http://rjptonline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacy%20and%20Technology;PID=2019-12-1-22 10.5958/0974-360X.2019.00022.2
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic Q Science (General)
spellingShingle Q Science (General)
Syed Abdul Azziz, Saripah Salbiah
Mukhtar, Mat Ropi
A.Hadi, A.Hamid
Mhd Bakri, Yuhanis
Abdulaimi, Ahmed Kareem Obaid
Awang, Khalijah
Hashim, Yumi Zuhanis Has-Yun
Alkaloids from Popowia perakensis and their dipeptidyl peptidase IV(DPP IV) inhibitors
description A study on the alkaloidal composition on the Malaysian Annonaceae species, i.e Popowia perakensis King has been carried out. Barks of Popowia perakensis were extracted with hexane, dichloromethane and methanol, respectively. Dichloromethane extract further underwent the acid base treatment to give the alkaloidal crude extract. Isolation of compounds was carried out using various chromatography techniques including column chromatography and thin layer chromatography. Spectroscopic methods notably 1H, 13C NMR, IR, UV and GCMS spectroscopy were utilized to identify pure compounds in addition to comparison of reported data. Two azaanthraquinones alkaloids namely cleistopholine 1 and 6-methoxycleistopholine 2 together with simple isoquinolone alkaloid, N-methylcorydaldine 3 had been isolated. All three alkaloids are known but they were isolated for the first time from this species. Cleistopholine 1 was tested for Dipeptidyl peptidase IV (DPP IV) inhibition to investigate its potential antidiabetic activities. Results revealed that this compound showed quite weak (6.26 %) inhibitory activities as compared to the positive control, Diprotin A (81.46 %). The quantity of the other two compounds was insufficient for the screening purposes.
format Article
author Syed Abdul Azziz, Saripah Salbiah
Mukhtar, Mat Ropi
A.Hadi, A.Hamid
Mhd Bakri, Yuhanis
Abdulaimi, Ahmed Kareem Obaid
Awang, Khalijah
Hashim, Yumi Zuhanis Has-Yun
author_facet Syed Abdul Azziz, Saripah Salbiah
Mukhtar, Mat Ropi
A.Hadi, A.Hamid
Mhd Bakri, Yuhanis
Abdulaimi, Ahmed Kareem Obaid
Awang, Khalijah
Hashim, Yumi Zuhanis Has-Yun
author_sort Syed Abdul Azziz, Saripah Salbiah
title Alkaloids from Popowia perakensis and their dipeptidyl peptidase IV(DPP IV) inhibitors
title_short Alkaloids from Popowia perakensis and their dipeptidyl peptidase IV(DPP IV) inhibitors
title_full Alkaloids from Popowia perakensis and their dipeptidyl peptidase IV(DPP IV) inhibitors
title_fullStr Alkaloids from Popowia perakensis and their dipeptidyl peptidase IV(DPP IV) inhibitors
title_full_unstemmed Alkaloids from Popowia perakensis and their dipeptidyl peptidase IV(DPP IV) inhibitors
title_sort alkaloids from popowia perakensis and their dipeptidyl peptidase iv(dpp iv) inhibitors
publisher Research Journal of Pharmacy and Technology
publishDate 2019
url http://irep.iium.edu.my/77248/1/77248_%20Alkaloids%20from%20Popowia%20perakensis.pdf
http://irep.iium.edu.my/77248/
http://rjptonline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacy%20and%20Technology;PID=2019-12-1-22
_version_ 1657565951606915072
score 13.211869

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