Alkaloids from Popowia perakensis and their dipeptidyl peptidase IV(DPP IV) inhibitors
A study on the alkaloidal composition on the Malaysian Annonaceae species, i.e Popowia perakensis King has been carried out. Barks of Popowia perakensis were extracted with hexane, dichloromethane and methanol, respectively. Dichloromethane extract further underwent the acid base treatment to give...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Research Journal of Pharmacy and Technology
2019
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/77248/1/77248_%20Alkaloids%20from%20Popowia%20perakensis.pdf http://irep.iium.edu.my/77248/ http://rjptonline.org/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacy%20and%20Technology;PID=2019-12-1-22 |
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| Summary: | A study on the alkaloidal composition on the Malaysian Annonaceae species, i.e Popowia perakensis King has
been carried out. Barks of Popowia perakensis were extracted with hexane, dichloromethane and methanol,
respectively. Dichloromethane extract further underwent the acid base treatment to give the alkaloidal crude
extract. Isolation of compounds was carried out using various chromatography techniques including column
chromatography and thin layer chromatography. Spectroscopic methods notably 1H, 13C NMR, IR, UV and GCMS spectroscopy were utilized to identify pure compounds in addition to comparison of reported data. Two
azaanthraquinones alkaloids namely cleistopholine 1 and 6-methoxycleistopholine 2 together with simple
isoquinolone alkaloid, N-methylcorydaldine 3 had been isolated. All three alkaloids are known but they were
isolated for the first time from this species. Cleistopholine 1 was tested for Dipeptidyl peptidase IV (DPP IV)
inhibition to investigate its potential antidiabetic activities. Results revealed that this compound showed quite
weak (6.26 %) inhibitory activities as compared to the positive control, Diprotin A (81.46 %). The quantity of
the other two compounds was insufficient for the screening purposes. |
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