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Review: In vitro study revealed sugar as anticancer constituent = İn vitro Çalışmalar Şekeri Bir Antikanser Bileşeni Olarak Gösteriyor; Literatür Derleme

The majority of deaths among cancer patients are attributed to the metastatic spread of cancer cells to vital organs instead of primary tumor outgrowth. Plus, cancer therapeutics which focusing on conventional chemotherapy is often toxic not only to tumor cells but also to normal cells and caused...

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Main Authors: Md Isa, Muhammad Lokman, Ramli, Nuramalina, Ismail, Isma Syahril, Shahbuddin, Munira, Mat Yusof, Afzan, Ramli, Roszaman
Format: Article
Language:English
Published: Dergi Park Akademik 2017
Subjects:
Q Science (General)
Online Access:http://irep.iium.edu.my/60397/1/Review_%20In%20Vitro%20Study%20Revealed%20Sugar%20As%20Anticancer%20Constituent%5B%23342808%5D-348896.pdf
http://irep.iium.edu.my/60397/
http://biotechealthresearch.com/index.php/bio/index
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spelling my.iium.irep.603972017-12-24T04:58:45Z http://irep.iium.edu.my/60397/ Review: In vitro study revealed sugar as anticancer constituent = İn vitro Çalışmalar Şekeri Bir Antikanser Bileşeni Olarak Gösteriyor; Literatür Derleme Md Isa, Muhammad Lokman Ramli, Nuramalina Ismail, Isma Syahril Shahbuddin, Munira Mat Yusof, Afzan Ramli, Roszaman Q Science (General) The majority of deaths among cancer patients are attributed to the metastatic spread of cancer cells to vital organs instead of primary tumor outgrowth. Plus, cancer therapeutics which focusing on conventional chemotherapy is often toxic not only to tumor cells but also to normal cells and caused their therapeutic use is limited. In this review, aberrant glycosylation is proposed to be a method of cancer diagnosis in order to identify cancer at its earliest and more treatable stage. Aberrant glycosylation is a universal feature of cancer cells. Glycosylation, the attachment of sugar moieties to protein, is a major form of post-translational modifi cation (PTM) that is observed in approximately half of all proteins. Certain glycan structures are well known markers for tumor progression and its availability and composition in the microenvironment may affect glycosylation of the cell. In order to understand the biological application of simple sugars as anticancer agents, it is vital to fundamentally investigate the relationship between simple sugars and cell proliferation using living cell lines in vitro. Various simple sugars have been studied previously in a number of cancer cell lines representing different evolutionary stages of cancer. It has been examined that there is a selective effect of individual simple sugars on the pattern of growth and metabolism of certain cell lines in tissue culture. The results from previous studies reported that certain simple sugars were able to alter the growth pattern and morphology of several cancer cell lines which indicate that sugars have antiproliferative effect on cancer cells. Dergi Park Akademik 2017-10-23 Article REM application/pdf en http://irep.iium.edu.my/60397/1/Review_%20In%20Vitro%20Study%20Revealed%20Sugar%20As%20Anticancer%20Constituent%5B%23342808%5D-348896.pdf Md Isa, Muhammad Lokman and Ramli, Nuramalina and Ismail, Isma Syahril and Shahbuddin, Munira and Mat Yusof, Afzan and Ramli, Roszaman (2017) Review: In vitro study revealed sugar as anticancer constituent = İn vitro Çalışmalar Şekeri Bir Antikanser Bileşeni Olarak Gösteriyor; Literatür Derleme. Journal of Biotechnology and Strategic Health Research, 1 (2). pp. 39-44. http://biotechealthresearch.com/index.php/bio/index
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic Q Science (General)
spellingShingle Q Science (General)
Md Isa, Muhammad Lokman
Ramli, Nuramalina
Ismail, Isma Syahril
Shahbuddin, Munira
Mat Yusof, Afzan
Ramli, Roszaman
Review: In vitro study revealed sugar as anticancer constituent = İn vitro Çalışmalar Şekeri Bir Antikanser Bileşeni Olarak Gösteriyor; Literatür Derleme
description The majority of deaths among cancer patients are attributed to the metastatic spread of cancer cells to vital organs instead of primary tumor outgrowth. Plus, cancer therapeutics which focusing on conventional chemotherapy is often toxic not only to tumor cells but also to normal cells and caused their therapeutic use is limited. In this review, aberrant glycosylation is proposed to be a method of cancer diagnosis in order to identify cancer at its earliest and more treatable stage. Aberrant glycosylation is a universal feature of cancer cells. Glycosylation, the attachment of sugar moieties to protein, is a major form of post-translational modifi cation (PTM) that is observed in approximately half of all proteins. Certain glycan structures are well known markers for tumor progression and its availability and composition in the microenvironment may affect glycosylation of the cell. In order to understand the biological application of simple sugars as anticancer agents, it is vital to fundamentally investigate the relationship between simple sugars and cell proliferation using living cell lines in vitro. Various simple sugars have been studied previously in a number of cancer cell lines representing different evolutionary stages of cancer. It has been examined that there is a selective effect of individual simple sugars on the pattern of growth and metabolism of certain cell lines in tissue culture. The results from previous studies reported that certain simple sugars were able to alter the growth pattern and morphology of several cancer cell lines which indicate that sugars have antiproliferative effect on cancer cells.
format Article
author Md Isa, Muhammad Lokman
Ramli, Nuramalina
Ismail, Isma Syahril
Shahbuddin, Munira
Mat Yusof, Afzan
Ramli, Roszaman
author_facet Md Isa, Muhammad Lokman
Ramli, Nuramalina
Ismail, Isma Syahril
Shahbuddin, Munira
Mat Yusof, Afzan
Ramli, Roszaman
author_sort Md Isa, Muhammad Lokman
title Review: In vitro study revealed sugar as anticancer constituent = İn vitro Çalışmalar Şekeri Bir Antikanser Bileşeni Olarak Gösteriyor; Literatür Derleme
title_short Review: In vitro study revealed sugar as anticancer constituent = İn vitro Çalışmalar Şekeri Bir Antikanser Bileşeni Olarak Gösteriyor; Literatür Derleme
title_full Review: In vitro study revealed sugar as anticancer constituent = İn vitro Çalışmalar Şekeri Bir Antikanser Bileşeni Olarak Gösteriyor; Literatür Derleme
title_fullStr Review: In vitro study revealed sugar as anticancer constituent = İn vitro Çalışmalar Şekeri Bir Antikanser Bileşeni Olarak Gösteriyor; Literatür Derleme
title_full_unstemmed Review: In vitro study revealed sugar as anticancer constituent = İn vitro Çalışmalar Şekeri Bir Antikanser Bileşeni Olarak Gösteriyor; Literatür Derleme
title_sort review: in vitro study revealed sugar as anticancer constituent = in vitro çalışmalar şekeri bir antikanser bileşeni olarak gösteriyor; literatür derleme
publisher Dergi Park Akademik
publishDate 2017
url http://irep.iium.edu.my/60397/1/Review_%20In%20Vitro%20Study%20Revealed%20Sugar%20As%20Anticancer%20Constituent%5B%23342808%5D-348896.pdf
http://irep.iium.edu.my/60397/
http://biotechealthresearch.com/index.php/bio/index
_version_ 1643615790630436864
score 13.211869

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