Review: In vitro study revealed sugar as anticancer constituent = İn vitro Çalışmalar Şekeri Bir Antikanser Bileşeni Olarak Gösteriyor; Literatür Derleme
The majority of deaths among cancer patients are attributed to the metastatic spread of cancer cells to vital organs instead of primary tumor outgrowth. Plus, cancer therapeutics which focusing on conventional chemotherapy is often toxic not only to tumor cells but also to normal cells and caused...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dergi Park Akademik
2017
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/60397/1/Review_%20In%20Vitro%20Study%20Revealed%20Sugar%20As%20Anticancer%20Constituent%5B%23342808%5D-348896.pdf http://irep.iium.edu.my/60397/ http://biotechealthresearch.com/index.php/bio/index |
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| Summary: | The majority of deaths among cancer patients are attributed to the metastatic spread of cancer cells to vital organs
instead of primary tumor outgrowth. Plus, cancer therapeutics which focusing on conventional chemotherapy is often
toxic not only to tumor cells but also to normal cells and caused their therapeutic use is limited. In this review, aberrant
glycosylation is proposed to be a method of cancer diagnosis in order to identify cancer at its earliest and more
treatable stage. Aberrant glycosylation is a universal feature of cancer cells. Glycosylation, the attachment of sugar
moieties to protein, is a major form of post-translational modifi cation (PTM) that is observed in approximately half of all
proteins. Certain glycan structures are well known markers for tumor progression and its availability and composition
in the microenvironment may affect glycosylation of the cell. In order to understand the biological application of simple
sugars as anticancer agents, it is vital to fundamentally investigate the relationship between simple sugars and cell
proliferation using living cell lines in vitro. Various simple sugars have been studied previously in a number of cancer
cell lines representing different evolutionary stages of cancer. It has been examined that there is a selective effect of
individual simple sugars on the pattern of growth and metabolism of certain cell lines in tissue culture. The results from
previous studies reported that certain simple sugars were able to alter the growth pattern and morphology of several
cancer cell lines which indicate that sugars have antiproliferative effect on cancer cells. |
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