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Label-free microfluidic blood cells micro-separator

Blood cells separation is of great interest in many biomedical applications because of its importance in sample preparation for both clinical diagnosis and therapeutic research. In this work, the micro-separator uses the combination of magnetophoresis with hydrodynamics in order to separate whit...

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Main Authors: Aissa, Foughalia, Ibrahim, Siti Noorjannah
Format: Conference or Workshop Item
Language:English
English
Published: IEEE 2016
Subjects:
TK452 Electric apparatus and materials. Electric circuits. Electric networks
TK7885 Computer engineering
Online Access:http://irep.iium.edu.my/51267/5/51267-new.pdf
http://irep.iium.edu.my/51267/8/51267_label%20free%20microfluidic_scopus.pdf
http://irep.iium.edu.my/51267/
http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=7514861&filter%3DAND%28p_IS_Number%3A7514818%29%26rowsPerPage%3D75
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spelling my.iium.irep.512672017-01-10T03:19:24Z http://irep.iium.edu.my/51267/ Label-free microfluidic blood cells micro-separator Aissa, Foughalia Ibrahim, Siti Noorjannah TK452 Electric apparatus and materials. Electric circuits. Electric networks TK7885 Computer engineering Blood cells separation is of great interest in many biomedical applications because of its importance in sample preparation for both clinical diagnosis and therapeutic research. In this work, the micro-separator uses the combination of magnetophoresis with hydrodynamics in order to separate white blood cells (WBCs) and red blood cells (RBCs) by taking into account the magnetization of the ferromagnetic elements and fluidic forces on the cells. The microfluidic devices can achieve label-free, continuous separation of WBCs and RBCs with relatively high efficiency. The micro-separator utilizes hydrodynamic force acting on cells within laminar flow, coupled with magnetophoresis force in novel U-shaped micro-channel. Here, we report the separation efficiency of the microfluidic device in continuous flow based on results of a 3D model simulation conducted in COMSOL Multiphysics. The proposed device enables label-free cell separation and thus, it can be a useful microfluidic component for lab-on-a-chip system and integrated biological and biomedical applications. IEEE 2016-05 Conference or Workshop Item REM application/pdf en http://irep.iium.edu.my/51267/5/51267-new.pdf application/pdf en http://irep.iium.edu.my/51267/8/51267_label%20free%20microfluidic_scopus.pdf Aissa, Foughalia and Ibrahim, Siti Noorjannah (2016) Label-free microfluidic blood cells micro-separator. In: 2016 Symposium on Design, Test, Integration and Packaging of MEMS/MOEMS (DTIP), 30th May-2nd June 2016, Budapest, Hungary. http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=7514861&filter%3DAND%28p_IS_Number%3A7514818%29%26rowsPerPage%3D75 10.1109/DTIP.2016.7514861
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic TK452 Electric apparatus and materials. Electric circuits. Electric networks
TK7885 Computer engineering
spellingShingle TK452 Electric apparatus and materials. Electric circuits. Electric networks
TK7885 Computer engineering
Aissa, Foughalia
Ibrahim, Siti Noorjannah
Label-free microfluidic blood cells micro-separator
description Blood cells separation is of great interest in many biomedical applications because of its importance in sample preparation for both clinical diagnosis and therapeutic research. In this work, the micro-separator uses the combination of magnetophoresis with hydrodynamics in order to separate white blood cells (WBCs) and red blood cells (RBCs) by taking into account the magnetization of the ferromagnetic elements and fluidic forces on the cells. The microfluidic devices can achieve label-free, continuous separation of WBCs and RBCs with relatively high efficiency. The micro-separator utilizes hydrodynamic force acting on cells within laminar flow, coupled with magnetophoresis force in novel U-shaped micro-channel. Here, we report the separation efficiency of the microfluidic device in continuous flow based on results of a 3D model simulation conducted in COMSOL Multiphysics. The proposed device enables label-free cell separation and thus, it can be a useful microfluidic component for lab-on-a-chip system and integrated biological and biomedical applications.
format Conference or Workshop Item
author Aissa, Foughalia
Ibrahim, Siti Noorjannah
author_facet Aissa, Foughalia
Ibrahim, Siti Noorjannah
author_sort Aissa, Foughalia
title Label-free microfluidic blood cells micro-separator
title_short Label-free microfluidic blood cells micro-separator
title_full Label-free microfluidic blood cells micro-separator
title_fullStr Label-free microfluidic blood cells micro-separator
title_full_unstemmed Label-free microfluidic blood cells micro-separator
title_sort label-free microfluidic blood cells micro-separator
publisher IEEE
publishDate 2016
url http://irep.iium.edu.my/51267/5/51267-new.pdf
http://irep.iium.edu.my/51267/8/51267_label%20free%20microfluidic_scopus.pdf
http://irep.iium.edu.my/51267/
http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=7514861&filter%3DAND%28p_IS_Number%3A7514818%29%26rowsPerPage%3D75
_version_ 1643613917413376000
score 13.211869

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