Label-free microfluidic blood cells micro-separator
Blood cells separation is of great interest in many biomedical applications because of its importance in sample preparation for both clinical diagnosis and therapeutic research. In this work, the micro-separator uses the combination of magnetophoresis with hydrodynamics in order to separate whit...
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| Main Authors: | , |
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| Format: | Conference or Workshop Item |
| Language: | English English |
| Published: |
IEEE
2016
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/51267/5/51267-new.pdf http://irep.iium.edu.my/51267/8/51267_label%20free%20microfluidic_scopus.pdf http://irep.iium.edu.my/51267/ http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=7514861&filter%3DAND%28p_IS_Number%3A7514818%29%26rowsPerPage%3D75 |
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| Summary: | Blood cells separation is of great interest in many
biomedical applications because of its importance in sample
preparation for both clinical diagnosis and therapeutic research.
In this work, the micro-separator uses the combination of
magnetophoresis with hydrodynamics in order to separate white
blood cells (WBCs) and red blood cells (RBCs) by taking into
account the magnetization of the ferromagnetic elements and
fluidic forces on the cells. The microfluidic devices can achieve
label-free, continuous separation of WBCs and RBCs with
relatively high efficiency. The micro-separator utilizes
hydrodynamic force acting on cells within laminar flow, coupled
with magnetophoresis force in novel U-shaped micro-channel.
Here, we report the separation efficiency of the microfluidic
device in continuous flow based on results of a 3D model
simulation conducted in COMSOL Multiphysics. The proposed
device enables label-free cell separation and thus, it can be a
useful microfluidic component for lab-on-a-chip system and
integrated biological and biomedical applications. |
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