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Antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on streptozotocin-induced diabetic rats = Aktiviti antihiperglisemik minyak ekstrak buah kelapa sawit Elaeis guineensis ke atas tikus diabetik Teraruh Streptozotocin

Hypoglycaemic and antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on normal and Streptozotocin-induced diabetic rats was studied. The oil palm fruit extract (OPF) were administered orally at different concentrations (100, 200 and 500 mg kg-1 b.w.) in fasting and post-prandial...

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Main Authors: Sharif, Mohd. Faez, Hamid, Muhajir, Ismail, Amin, Adam, Zainah
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2015
Subjects:
QH301 Biology
Online Access:http://irep.iium.edu.my/45898/1/10876-29609-1-SM.pdf
http://irep.iium.edu.my/45898/
http://ejournals.ukm.my/jskm/article/view/10876
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spelling my.iium.irep.458982017-11-29T07:19:59Z http://irep.iium.edu.my/45898/ Antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on streptozotocin-induced diabetic rats = Aktiviti antihiperglisemik minyak ekstrak buah kelapa sawit Elaeis guineensis ke atas tikus diabetik Teraruh Streptozotocin Sharif, Mohd. Faez Hamid, Muhajir Ismail, Amin Adam, Zainah QH301 Biology Hypoglycaemic and antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on normal and Streptozotocin-induced diabetic rats was studied. The oil palm fruit extract (OPF) were administered orally at different concentrations (100, 200 and 500 mg kg-1 b.w.) in fasting and post-prandial rats. Hypoglycaemia was not observed in the group of normal rats treated with OPF. In fasting rats, OPF (500 mg kg-1 b.w.) has caused the blood glucose level (BGL) to reduce significantly. For post-prandial diabetic rats, the antihyperglycemic activity was observed after OPF treatment at concentrations 200 and 500 mg kg-1. Chronic OPF treatments (for 28 days) had increased the diabetic rat’s body weight and reduced BGL as well as improved plasma insulin secretion. The result of this study suggests E. guineensis palm fruit extract show evidence of antihyperglycemic properties from the reduction of the BGL in diabetic rats. Aktiviti hipoglisemik dan antihiperglisemik ekstrak buah kelapa sawit Elaeis guineensis terhadap tikus normal dan tikus diabetik aruhan- Streptozotocin dikaji. Ekstrak minyak buah kelapa sawit (OPF) diberi secara oral pada kepekatan berbeza (100, 200 dan 500 mg kg-1 b.w.) kepada tikus puasa dan posprandial. Hipoglisemia tidak berlaku dalam kumpulan tikus normal yang dirawat dengan OPF. Dalam tikus puasa, OPF (500 mg kg-1 b.w.) telah menyebabkan aras glukosa darah (BGL) turun secara bererti. Bagi tikus diabetik posprandial, aktiviti anti hiperglisemik telah diperhatikan selepas rawatan OPF pada kepekatan 200 dan 500 mg kg-1. Rawatan OPF secara kronik (selama 28 hari) meningkatkan berat badan tikus diabetik dan menurunkan BGL secara bererti serta memperbaiki rembesan plasma insulin. Keputusan kajian ini mencadangkan, ekstrak buah kelapa sawit E. guineensis menunjukkan sifat antihiperglisemik dengan penurunan BGL tikus diabetik. Penerbit Universiti Kebangsaan Malaysia 2015-07-18 Article REM application/pdf en http://irep.iium.edu.my/45898/1/10876-29609-1-SM.pdf Sharif, Mohd. Faez and Hamid, Muhajir and Ismail, Amin and Adam, Zainah (2015) Antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on streptozotocin-induced diabetic rats = Aktiviti antihiperglisemik minyak ekstrak buah kelapa sawit Elaeis guineensis ke atas tikus diabetik Teraruh Streptozotocin. Jurnal Sains Kesihatan Malaysia, 13 (2). pp. 37-43. ISSN 1675-8161 http://ejournals.ukm.my/jskm/article/view/10876
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic QH301 Biology
spellingShingle QH301 Biology
Sharif, Mohd. Faez
Hamid, Muhajir
Ismail, Amin
Adam, Zainah
Antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on streptozotocin-induced diabetic rats = Aktiviti antihiperglisemik minyak ekstrak buah kelapa sawit Elaeis guineensis ke atas tikus diabetik Teraruh Streptozotocin
description Hypoglycaemic and antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on normal and Streptozotocin-induced diabetic rats was studied. The oil palm fruit extract (OPF) were administered orally at different concentrations (100, 200 and 500 mg kg-1 b.w.) in fasting and post-prandial rats. Hypoglycaemia was not observed in the group of normal rats treated with OPF. In fasting rats, OPF (500 mg kg-1 b.w.) has caused the blood glucose level (BGL) to reduce significantly. For post-prandial diabetic rats, the antihyperglycemic activity was observed after OPF treatment at concentrations 200 and 500 mg kg-1. Chronic OPF treatments (for 28 days) had increased the diabetic rat’s body weight and reduced BGL as well as improved plasma insulin secretion. The result of this study suggests E. guineensis palm fruit extract show evidence of antihyperglycemic properties from the reduction of the BGL in diabetic rats. Aktiviti hipoglisemik dan antihiperglisemik ekstrak buah kelapa sawit Elaeis guineensis terhadap tikus normal dan tikus diabetik aruhan- Streptozotocin dikaji. Ekstrak minyak buah kelapa sawit (OPF) diberi secara oral pada kepekatan berbeza (100, 200 dan 500 mg kg-1 b.w.) kepada tikus puasa dan posprandial. Hipoglisemia tidak berlaku dalam kumpulan tikus normal yang dirawat dengan OPF. Dalam tikus puasa, OPF (500 mg kg-1 b.w.) telah menyebabkan aras glukosa darah (BGL) turun secara bererti. Bagi tikus diabetik posprandial, aktiviti anti hiperglisemik telah diperhatikan selepas rawatan OPF pada kepekatan 200 dan 500 mg kg-1. Rawatan OPF secara kronik (selama 28 hari) meningkatkan berat badan tikus diabetik dan menurunkan BGL secara bererti serta memperbaiki rembesan plasma insulin. Keputusan kajian ini mencadangkan, ekstrak buah kelapa sawit E. guineensis menunjukkan sifat antihiperglisemik dengan penurunan BGL tikus diabetik.
format Article
author Sharif, Mohd. Faez
Hamid, Muhajir
Ismail, Amin
Adam, Zainah
author_facet Sharif, Mohd. Faez
Hamid, Muhajir
Ismail, Amin
Adam, Zainah
author_sort Sharif, Mohd. Faez
title Antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on streptozotocin-induced diabetic rats = Aktiviti antihiperglisemik minyak ekstrak buah kelapa sawit Elaeis guineensis ke atas tikus diabetik Teraruh Streptozotocin
title_short Antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on streptozotocin-induced diabetic rats = Aktiviti antihiperglisemik minyak ekstrak buah kelapa sawit Elaeis guineensis ke atas tikus diabetik Teraruh Streptozotocin
title_full Antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on streptozotocin-induced diabetic rats = Aktiviti antihiperglisemik minyak ekstrak buah kelapa sawit Elaeis guineensis ke atas tikus diabetik Teraruh Streptozotocin
title_fullStr Antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on streptozotocin-induced diabetic rats = Aktiviti antihiperglisemik minyak ekstrak buah kelapa sawit Elaeis guineensis ke atas tikus diabetik Teraruh Streptozotocin
title_full_unstemmed Antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on streptozotocin-induced diabetic rats = Aktiviti antihiperglisemik minyak ekstrak buah kelapa sawit Elaeis guineensis ke atas tikus diabetik Teraruh Streptozotocin
title_sort antihyperglycemic activity of oil palm elaeis guineensis fruit extract on streptozotocin-induced diabetic rats = aktiviti antihiperglisemik minyak ekstrak buah kelapa sawit elaeis guineensis ke atas tikus diabetik teraruh streptozotocin
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2015
url http://irep.iium.edu.my/45898/1/10876-29609-1-SM.pdf
http://irep.iium.edu.my/45898/
http://ejournals.ukm.my/jskm/article/view/10876
_version_ 1643612880511172608
score 13.211869

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