Antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on streptozotocin-induced diabetic rats = Aktiviti antihiperglisemik minyak ekstrak buah kelapa sawit Elaeis guineensis ke atas tikus diabetik Teraruh Streptozotocin
Hypoglycaemic and antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on normal and Streptozotocin-induced diabetic rats was studied. The oil palm fruit extract (OPF) were administered orally at different concentrations (100, 200 and 500 mg kg-1 b.w.) in fasting and post-prandial...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2015
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/45898/1/10876-29609-1-SM.pdf http://irep.iium.edu.my/45898/ http://ejournals.ukm.my/jskm/article/view/10876 |
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| Summary: | Hypoglycaemic and antihyperglycemic activity of oil palm Elaeis guineensis fruit extract on normal and Streptozotocin-induced diabetic rats was studied. The oil palm fruit extract (OPF) were administered orally at different concentrations (100, 200 and 500 mg kg-1 b.w.) in fasting and post-prandial rats. Hypoglycaemia was not observed in the group of normal rats treated with OPF. In fasting rats, OPF (500 mg kg-1 b.w.) has caused the blood glucose level (BGL) to reduce significantly. For post-prandial diabetic rats, the antihyperglycemic activity was observed after OPF treatment at concentrations 200 and 500 mg kg-1. Chronic OPF treatments (for 28 days) had increased the diabetic rat’s body weight and reduced BGL as well as improved plasma insulin secretion. The result of this study suggests E. guineensis palm fruit extract show evidence of antihyperglycemic properties from the reduction of the BGL in diabetic rats.
Aktiviti hipoglisemik dan antihiperglisemik ekstrak buah kelapa sawit Elaeis guineensis terhadap tikus normal dan
tikus diabetik aruhan- Streptozotocin dikaji. Ekstrak minyak buah kelapa sawit (OPF) diberi secara oral pada kepekatan
berbeza (100, 200 dan 500 mg kg-1 b.w.) kepada tikus puasa dan posprandial. Hipoglisemia tidak berlaku dalam kumpulan
tikus normal yang dirawat dengan OPF. Dalam tikus puasa, OPF (500 mg kg-1 b.w.) telah menyebabkan aras glukosa
darah (BGL) turun secara bererti. Bagi tikus diabetik posprandial, aktiviti anti hiperglisemik telah diperhatikan selepas
rawatan OPF pada kepekatan 200 dan 500 mg kg-1. Rawatan OPF secara kronik (selama 28 hari) meningkatkan berat
badan tikus diabetik dan menurunkan BGL secara bererti serta memperbaiki rembesan plasma insulin. Keputusan kajian
ini mencadangkan, ekstrak buah kelapa sawit E. guineensis menunjukkan sifat antihiperglisemik dengan penurunan BGL
tikus diabetik. |
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