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Preparation and characterization of nigella sative microemulsions

The aims of this study were to develop and characterize an oil-in-water (o/w) Nigella sativa (N. sativa) microemulsion. The microemulsions were prepared by drop-wise titration of N. sativa oil into mixtures of surfactant blends (Span 20, Span 80, Tween 20, Tween 80, Tween 85) and water. All tran...

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Main Authors: Mohd Nor, Nor Hafizah, Mohd Shafri, Mohd Affendi, Mohamed, Farahidah
Format: Article
Language:English
Published: Academic Sciences 2014
Subjects:
R Medicine (General)
Online Access:http://irep.iium.edu.my/39617/1/2431-9690-1-PB.pdf
http://irep.iium.edu.my/39617/
http://www.ijppsjournal.com/contents.htm
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spelling my.iium.irep.396172014-12-15T00:37:21Z http://irep.iium.edu.my/39617/ Preparation and characterization of nigella sative microemulsions Mohd Nor, Nor Hafizah Mohd Shafri, Mohd Affendi Mohamed, Farahidah R Medicine (General) The aims of this study were to develop and characterize an oil-in-water (o/w) Nigella sativa (N. sativa) microemulsion. The microemulsions were prepared by drop-wise titration of N. sativa oil into mixtures of surfactant blends (Span 20, Span 80, Tween 20, Tween 80, Tween 85) and water. All transparent ternary mixtures were characterized for their viscosity and droplet size. The stability of the microemulsion was evaluated by subjecting them to stressful conditions, namely centrifugation (2000 g for 20 minutes) and heating in a drying oven (60 °C to 105 °C for 5 hours) and the droplet size was determined following one month storage at room temperature (25 °C) thereafter. Based on the results, a phase diagram was constructed from corresponding volumes of those 3 components. N. sativa mixtures (ranging from 7.4% to 10.7%) prepared at HLB 16 of surfactant blends (Tween 20: Tween 80; 6:4) with water (ranging from 17.9% to 18.5%) yielded transparent liquids. The constructed phase diagram displayed regions of a few types of microemulsion and emulsion. Interestingly, droplet size of freshly prepared mixtures was wider in range (5 to 15.6 nm) than the size following stressful condition (11.3 to 12.4 nm). It was concluded that N. sativa oil could be formulated into microemulsion at specific HLB value of surfactant blends. Such system was envisaged to enable routine rapid in vitro test on neuron cell lines loaded with N. sativa oil or possibly other lipophilic materials whenever viewing of neurite extension is required. Academic Sciences 2014 Article REM application/pdf en http://irep.iium.edu.my/39617/1/2431-9690-1-PB.pdf Mohd Nor, Nor Hafizah and Mohd Shafri, Mohd Affendi and Mohamed, Farahidah (2014) Preparation and characterization of nigella sative microemulsions. International Journal of Pharmacy and Pharmaceutical Sciences, 6 (9). pp. 485-489. ISSN 0975-1491 http://www.ijppsjournal.com/contents.htm
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Mohd Nor, Nor Hafizah
Mohd Shafri, Mohd Affendi
Mohamed, Farahidah
Preparation and characterization of nigella sative microemulsions
description The aims of this study were to develop and characterize an oil-in-water (o/w) Nigella sativa (N. sativa) microemulsion. The microemulsions were prepared by drop-wise titration of N. sativa oil into mixtures of surfactant blends (Span 20, Span 80, Tween 20, Tween 80, Tween 85) and water. All transparent ternary mixtures were characterized for their viscosity and droplet size. The stability of the microemulsion was evaluated by subjecting them to stressful conditions, namely centrifugation (2000 g for 20 minutes) and heating in a drying oven (60 °C to 105 °C for 5 hours) and the droplet size was determined following one month storage at room temperature (25 °C) thereafter. Based on the results, a phase diagram was constructed from corresponding volumes of those 3 components. N. sativa mixtures (ranging from 7.4% to 10.7%) prepared at HLB 16 of surfactant blends (Tween 20: Tween 80; 6:4) with water (ranging from 17.9% to 18.5%) yielded transparent liquids. The constructed phase diagram displayed regions of a few types of microemulsion and emulsion. Interestingly, droplet size of freshly prepared mixtures was wider in range (5 to 15.6 nm) than the size following stressful condition (11.3 to 12.4 nm). It was concluded that N. sativa oil could be formulated into microemulsion at specific HLB value of surfactant blends. Such system was envisaged to enable routine rapid in vitro test on neuron cell lines loaded with N. sativa oil or possibly other lipophilic materials whenever viewing of neurite extension is required.
format Article
author Mohd Nor, Nor Hafizah
Mohd Shafri, Mohd Affendi
Mohamed, Farahidah
author_facet Mohd Nor, Nor Hafizah
Mohd Shafri, Mohd Affendi
Mohamed, Farahidah
author_sort Mohd Nor, Nor Hafizah
title Preparation and characterization of nigella sative microemulsions
title_short Preparation and characterization of nigella sative microemulsions
title_full Preparation and characterization of nigella sative microemulsions
title_fullStr Preparation and characterization of nigella sative microemulsions
title_full_unstemmed Preparation and characterization of nigella sative microemulsions
title_sort preparation and characterization of nigella sative microemulsions
publisher Academic Sciences
publishDate 2014
url http://irep.iium.edu.my/39617/1/2431-9690-1-PB.pdf
http://irep.iium.edu.my/39617/
http://www.ijppsjournal.com/contents.htm
_version_ 1643611671347855360
score 13.211869

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