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Unveiling a rarity: myoepithelial neoplasms of soft tissue

Introduction: Myoepithelial neoplasms of soft tissue represent a heterogeneous group of tumours classified as benign (myoepithelioma and mixed tumour) or malignant (myoepithelial carcinoma). Case Presentation: We report the case of a 42-year-old woman with no prior medical conditions who present...

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Main Authors: Abd. Fuaat, Azliana, Tuan Sharif, Sharifah Emilia, Hamdan, Asmah Hanim, Ahmad Affandi, Khairunisa, Azmi, Siti Nurhanisah
Format: Proceeding Paper
Language:English
Published: Academy of Medicine Malaysia 2024
Subjects:
RB Pathology
Online Access:http://irep.iium.edu.my/117421/7/117421_Unveiling%20a%20rarity.pdf
http://irep.iium.edu.my/117421/
https://www.mjpath.org.my/
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spelling my.iium.irep.1174212025-01-08T08:55:15Z http://irep.iium.edu.my/117421/ Unveiling a rarity: myoepithelial neoplasms of soft tissue Abd. Fuaat, Azliana Tuan Sharif, Sharifah Emilia Hamdan, Asmah Hanim Ahmad Affandi, Khairunisa Azmi, Siti Nurhanisah RB Pathology Introduction: Myoepithelial neoplasms of soft tissue represent a heterogeneous group of tumours classified as benign (myoepithelioma and mixed tumour) or malignant (myoepithelial carcinoma). Case Presentation: We report the case of a 42-year-old woman with no prior medical conditions who presented with a right arm mass persisting for 15 years. Despite its gradual increase in size, she remained asymptomatic. Examination revealed a substantial mass in her right arm, with well-defined borders, a soft to firm texture, and a smooth surface covered by normal skin. MRI of the right humerus showed a lobulated solid-cystic mass, predominantly cystic, at the postero-medial aspect of the proximal humerus, measuring 7.1 × 7.6 × 11.5 cm. The mass was surgically excised. Gross examination revealed a well-circumscribed, lobulated-brownish mass measuring 120 × 80 × 60 mm. Cut section showed a mixture of solid and cystic components, with the solid areas displaying a brownish surface without necrosis. The cystic areas were multiloculated, ranging from 1-5 mm in diameter, and contained brownish fluid. Microscopic and immunohistochemical analysis indicated features of a myoepithelial neoplasm of soft tissue. Discussion: Myoepithelial neoplasms of soft tissue exhibit a spectrum of morphologic patterns, making them difficult to distinguish from other neoplasms. There are no definitive criteria for malignancy for this tumour. While most morphologically benign myoepithelial neoplasms of soft tissue behave in a benign manner, there is approximately a 20% risk of local recurrence. Therefore, complete excision with clear margins is crucial. Conclusion: Recognition of this rare tumour is essential for planning management and predicting prognosis. Academy of Medicine Malaysia 2024-12 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/117421/7/117421_Unveiling%20a%20rarity.pdf Abd. Fuaat, Azliana and Tuan Sharif, Sharifah Emilia and Hamdan, Asmah Hanim and Ahmad Affandi, Khairunisa and Azmi, Siti Nurhanisah (2024) Unveiling a rarity: myoepithelial neoplasms of soft tissue. In: The 20th Annual Scientific Meeting, College of Pathologists, Academy of Medicine of Malaysia, 5-6 August 2024, Swissbell Hotel Kuantan. https://www.mjpath.org.my/
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RB Pathology
spellingShingle RB Pathology
Abd. Fuaat, Azliana
Tuan Sharif, Sharifah Emilia
Hamdan, Asmah Hanim
Ahmad Affandi, Khairunisa
Azmi, Siti Nurhanisah
Unveiling a rarity: myoepithelial neoplasms of soft tissue
description Introduction: Myoepithelial neoplasms of soft tissue represent a heterogeneous group of tumours classified as benign (myoepithelioma and mixed tumour) or malignant (myoepithelial carcinoma). Case Presentation: We report the case of a 42-year-old woman with no prior medical conditions who presented with a right arm mass persisting for 15 years. Despite its gradual increase in size, she remained asymptomatic. Examination revealed a substantial mass in her right arm, with well-defined borders, a soft to firm texture, and a smooth surface covered by normal skin. MRI of the right humerus showed a lobulated solid-cystic mass, predominantly cystic, at the postero-medial aspect of the proximal humerus, measuring 7.1 × 7.6 × 11.5 cm. The mass was surgically excised. Gross examination revealed a well-circumscribed, lobulated-brownish mass measuring 120 × 80 × 60 mm. Cut section showed a mixture of solid and cystic components, with the solid areas displaying a brownish surface without necrosis. The cystic areas were multiloculated, ranging from 1-5 mm in diameter, and contained brownish fluid. Microscopic and immunohistochemical analysis indicated features of a myoepithelial neoplasm of soft tissue. Discussion: Myoepithelial neoplasms of soft tissue exhibit a spectrum of morphologic patterns, making them difficult to distinguish from other neoplasms. There are no definitive criteria for malignancy for this tumour. While most morphologically benign myoepithelial neoplasms of soft tissue behave in a benign manner, there is approximately a 20% risk of local recurrence. Therefore, complete excision with clear margins is crucial. Conclusion: Recognition of this rare tumour is essential for planning management and predicting prognosis.
format Proceeding Paper
author Abd. Fuaat, Azliana
Tuan Sharif, Sharifah Emilia
Hamdan, Asmah Hanim
Ahmad Affandi, Khairunisa
Azmi, Siti Nurhanisah
author_facet Abd. Fuaat, Azliana
Tuan Sharif, Sharifah Emilia
Hamdan, Asmah Hanim
Ahmad Affandi, Khairunisa
Azmi, Siti Nurhanisah
author_sort Abd. Fuaat, Azliana
title Unveiling a rarity: myoepithelial neoplasms of soft tissue
title_short Unveiling a rarity: myoepithelial neoplasms of soft tissue
title_full Unveiling a rarity: myoepithelial neoplasms of soft tissue
title_fullStr Unveiling a rarity: myoepithelial neoplasms of soft tissue
title_full_unstemmed Unveiling a rarity: myoepithelial neoplasms of soft tissue
title_sort unveiling a rarity: myoepithelial neoplasms of soft tissue
publisher Academy of Medicine Malaysia
publishDate 2024
url http://irep.iium.edu.my/117421/7/117421_Unveiling%20a%20rarity.pdf
http://irep.iium.edu.my/117421/
https://www.mjpath.org.my/
_version_ 1821105144330190848
score 13.23648

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