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Flavonoid diversity and roles in the Lipopolysaccharide mediated inflammatory response of Monocytes and Macrophages

Targeting lipopolysaccharide (LPS)/toll-like receptor 4 signaling in mononuclear phagocytes has been explored for the treatment of inflammation and inflammation-related disorders. However, only a few key targets have been translated into clinical applications. Flavonoids, a class of ubiquitous plant...

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Main Authors: Rullah, Kamal, Shamsudin, Nur Farisya, Koeberle, Andreas, Tham, Chau Ling, Mohd Aluwi, Mohd Fadhlizil Fasihi, Leong, Sze Wei, Jantan, Ibrahim, Lam, Kok Wai
Format: Article
Language:English
English
English
Published: Taylor & Francis 2024
Subjects:
RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:http://irep.iium.edu.my/116793/19/116793_Flavonoid%20diversity%20and%20roles%20in%20the%20Lipopolysaccharide%20mediated.pdf
http://irep.iium.edu.my/116793/20/116793_Flavonoid%20diversity%20and%20roles%20in%20the%20Lipopolysaccharide%20mediated_SCOPUS.pdf
http://irep.iium.edu.my/116793/21/116793_Flavonoid%20diversity%20and%20roles%20in%20the%20Lipopolysaccharide%20mediated_WOS.pdf
http://irep.iium.edu.my/116793/
https://www.tandfonline.com/doi/abs/10.4155/fmc-2023-0174
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spelling my.iium.irep.1167932024-12-18T00:17:39Z http://irep.iium.edu.my/116793/ Flavonoid diversity and roles in the Lipopolysaccharide mediated inflammatory response of Monocytes and Macrophages Rullah, Kamal Shamsudin, Nur Farisya Koeberle, Andreas Tham, Chau Ling Mohd Aluwi, Mohd Fadhlizil Fasihi Leong, Sze Wei Jantan, Ibrahim Lam, Kok Wai RS403 Materia Medica-Pharmaceutical Chemistry Targeting lipopolysaccharide (LPS)/toll-like receptor 4 signaling in mononuclear phagocytes has been explored for the treatment of inflammation and inflammation-related disorders. However, only a few key targets have been translated into clinical applications. Flavonoids, a class of ubiquitous plant secondary metabolites, possess a privileged scaffold which serves as a valuable template for designing pharmacologically active compounds directed against diseases with inflammatory components. This perspective provides a general overview of the diversity of flavonoids and their multifaceted mechanisms that interfere with LPS-induced signaling in monocytes and macrophages. Focus is placed on flavonoids targeting MD-2, IκB kinases, c-Jun N-terminal kinases, extracellular signal-regulated kinase, p38 MAPK and PI3K/Akt or modulating LPS-related gene expression. Taylor & Francis 2024-01-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/116793/19/116793_Flavonoid%20diversity%20and%20roles%20in%20the%20Lipopolysaccharide%20mediated.pdf application/pdf en http://irep.iium.edu.my/116793/20/116793_Flavonoid%20diversity%20and%20roles%20in%20the%20Lipopolysaccharide%20mediated_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/116793/21/116793_Flavonoid%20diversity%20and%20roles%20in%20the%20Lipopolysaccharide%20mediated_WOS.pdf Rullah, Kamal and Shamsudin, Nur Farisya and Koeberle, Andreas and Tham, Chau Ling and Mohd Aluwi, Mohd Fadhlizil Fasihi and Leong, Sze Wei and Jantan, Ibrahim and Lam, Kok Wai (2024) Flavonoid diversity and roles in the Lipopolysaccharide mediated inflammatory response of Monocytes and Macrophages. Future Medicinal Chemistry, 16 (1). pp. 75-99. ISSN 1756-8927 https://www.tandfonline.com/doi/abs/10.4155/fmc-2023-0174 10.4155/fmc-2023-0174
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
English
topic RS403 Materia Medica-Pharmaceutical Chemistry
spellingShingle RS403 Materia Medica-Pharmaceutical Chemistry
Rullah, Kamal
Shamsudin, Nur Farisya
Koeberle, Andreas
Tham, Chau Ling
Mohd Aluwi, Mohd Fadhlizil Fasihi
Leong, Sze Wei
Jantan, Ibrahim
Lam, Kok Wai
Flavonoid diversity and roles in the Lipopolysaccharide mediated inflammatory response of Monocytes and Macrophages
description Targeting lipopolysaccharide (LPS)/toll-like receptor 4 signaling in mononuclear phagocytes has been explored for the treatment of inflammation and inflammation-related disorders. However, only a few key targets have been translated into clinical applications. Flavonoids, a class of ubiquitous plant secondary metabolites, possess a privileged scaffold which serves as a valuable template for designing pharmacologically active compounds directed against diseases with inflammatory components. This perspective provides a general overview of the diversity of flavonoids and their multifaceted mechanisms that interfere with LPS-induced signaling in monocytes and macrophages. Focus is placed on flavonoids targeting MD-2, IκB kinases, c-Jun N-terminal kinases, extracellular signal-regulated kinase, p38 MAPK and PI3K/Akt or modulating LPS-related gene expression.
format Article
author Rullah, Kamal
Shamsudin, Nur Farisya
Koeberle, Andreas
Tham, Chau Ling
Mohd Aluwi, Mohd Fadhlizil Fasihi
Leong, Sze Wei
Jantan, Ibrahim
Lam, Kok Wai
author_facet Rullah, Kamal
Shamsudin, Nur Farisya
Koeberle, Andreas
Tham, Chau Ling
Mohd Aluwi, Mohd Fadhlizil Fasihi
Leong, Sze Wei
Jantan, Ibrahim
Lam, Kok Wai
author_sort Rullah, Kamal
title Flavonoid diversity and roles in the Lipopolysaccharide mediated inflammatory response of Monocytes and Macrophages
title_short Flavonoid diversity and roles in the Lipopolysaccharide mediated inflammatory response of Monocytes and Macrophages
title_full Flavonoid diversity and roles in the Lipopolysaccharide mediated inflammatory response of Monocytes and Macrophages
title_fullStr Flavonoid diversity and roles in the Lipopolysaccharide mediated inflammatory response of Monocytes and Macrophages
title_full_unstemmed Flavonoid diversity and roles in the Lipopolysaccharide mediated inflammatory response of Monocytes and Macrophages
title_sort flavonoid diversity and roles in the lipopolysaccharide mediated inflammatory response of monocytes and macrophages
publisher Taylor & Francis
publishDate 2024
url http://irep.iium.edu.my/116793/19/116793_Flavonoid%20diversity%20and%20roles%20in%20the%20Lipopolysaccharide%20mediated.pdf
http://irep.iium.edu.my/116793/20/116793_Flavonoid%20diversity%20and%20roles%20in%20the%20Lipopolysaccharide%20mediated_SCOPUS.pdf
http://irep.iium.edu.my/116793/21/116793_Flavonoid%20diversity%20and%20roles%20in%20the%20Lipopolysaccharide%20mediated_WOS.pdf
http://irep.iium.edu.my/116793/
https://www.tandfonline.com/doi/abs/10.4155/fmc-2023-0174
_version_ 1818833738068393984
score 13.223943

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