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Efficacy of antioxidant supplementation on sperm quality in men with oligoasthenoteratozoospermia

Introduction Evidence of a positive relationship between the intake of antioxidant supplements and the improvement of sperm parameters has been reported mainly in European and American populations and very little in Asian populations. Hence, we aimed to investigate the association between antioxid...

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Main Authors: Sarmidi, Sardiana, Abdul Wahab, Azantee Yazmie, Azizan, Azha Syahril, Mubarak, Sarah, Yussoff, Noor Haliza
Format: Article
Language:English
Published: JRBF Online Publications 2022
Subjects:
Q Science (General)
R Medicine (General)
Online Access:http://irep.iium.edu.my/110290/1/110290_EFFICACY%20OF%20ANTIOXIDANT%20SUPPLEMENTATION%20ON%20SPERM%20QUALITY.pdf
http://irep.iium.edu.my/110290/
https://www.ivf-hub.net/journal-archive-new/2022-2/
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spelling my.iium.irep.1102902024-01-24T03:39:20Z http://irep.iium.edu.my/110290/ Efficacy of antioxidant supplementation on sperm quality in men with oligoasthenoteratozoospermia Sarmidi, Sardiana Abdul Wahab, Azantee Yazmie Azizan, Azha Syahril Mubarak, Sarah Yussoff, Noor Haliza Q Science (General) R Medicine (General) Introduction Evidence of a positive relationship between the intake of antioxidant supplements and the improvement of sperm parameters has been reported mainly in European and American populations and very little in Asian populations. Hence, we aimed to investigate the association between antioxidant supplement intake (i.e., Profertil®) and sperm parameters in Malaysian men with Oligoasthenoteratozoospermia (OAT). Materials and methods: This is a single-centre retrospective study that investigated a total of 195 men with OAT whose female partners underwent ART treatment between 2016 and 2021. They were divided into 2 groups; a treatment group where male patients received two daily capsules of the antioxidant supplement (Profertil®) for 3 months (n = 92) and a control group where no micronutrient was given to the male partner (n = 103). Sperm parameters, including semen volume, sperm concentration, progressive motility, total motility, and morphology, were analyzed before and after treatment. A Kruskal-Wallis test was performed to compare the median levels of the sperm parameters. A Chi-square test was performed to compare the frequencies of normal morphology between the studied groups. Results: Demographic and baseline characteristics showed no significant differences except for the mean age of the husband and the etiology of infertility (p<0.05). When compared to their baseline sperm quality, men receiving Profertil® had highly significant increases in median sperm concentration (p<0.0001), motility (p<0.0001), progressive motility (p<0.0001), total sperm count (p<0.0001), total sperm motility (p=0.01) and total progressive motility (p<0.0001). Moreover, sperm abnormality of a total of 24 (26.1%) men improved after receiving Profertil® (p=0.013). Conclusion: Our data showed that antioxidants (Profertil®) have a positive effect on semen parameters in men with OAT JRBF Online Publications 2022 Article PeerReviewed application/pdf en http://irep.iium.edu.my/110290/1/110290_EFFICACY%20OF%20ANTIOXIDANT%20SUPPLEMENTATION%20ON%20SPERM%20QUALITY.pdf Sarmidi, Sardiana and Abdul Wahab, Azantee Yazmie and Azizan, Azha Syahril and Mubarak, Sarah and Yussoff, Noor Haliza (2022) Efficacy of antioxidant supplementation on sperm quality in men with oligoasthenoteratozoospermia. J Reprod Biotechnol Fertil. pp. 53-65. E-ISSN 2058-9158 https://www.ivf-hub.net/journal-archive-new/2022-2/
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic Q Science (General)
R Medicine (General)
spellingShingle Q Science (General)
R Medicine (General)
Sarmidi, Sardiana
Abdul Wahab, Azantee Yazmie
Azizan, Azha Syahril
Mubarak, Sarah
Yussoff, Noor Haliza
Efficacy of antioxidant supplementation on sperm quality in men with oligoasthenoteratozoospermia
description Introduction Evidence of a positive relationship between the intake of antioxidant supplements and the improvement of sperm parameters has been reported mainly in European and American populations and very little in Asian populations. Hence, we aimed to investigate the association between antioxidant supplement intake (i.e., Profertil®) and sperm parameters in Malaysian men with Oligoasthenoteratozoospermia (OAT). Materials and methods: This is a single-centre retrospective study that investigated a total of 195 men with OAT whose female partners underwent ART treatment between 2016 and 2021. They were divided into 2 groups; a treatment group where male patients received two daily capsules of the antioxidant supplement (Profertil®) for 3 months (n = 92) and a control group where no micronutrient was given to the male partner (n = 103). Sperm parameters, including semen volume, sperm concentration, progressive motility, total motility, and morphology, were analyzed before and after treatment. A Kruskal-Wallis test was performed to compare the median levels of the sperm parameters. A Chi-square test was performed to compare the frequencies of normal morphology between the studied groups. Results: Demographic and baseline characteristics showed no significant differences except for the mean age of the husband and the etiology of infertility (p<0.05). When compared to their baseline sperm quality, men receiving Profertil® had highly significant increases in median sperm concentration (p<0.0001), motility (p<0.0001), progressive motility (p<0.0001), total sperm count (p<0.0001), total sperm motility (p=0.01) and total progressive motility (p<0.0001). Moreover, sperm abnormality of a total of 24 (26.1%) men improved after receiving Profertil® (p=0.013). Conclusion: Our data showed that antioxidants (Profertil®) have a positive effect on semen parameters in men with OAT
format Article
author Sarmidi, Sardiana
Abdul Wahab, Azantee Yazmie
Azizan, Azha Syahril
Mubarak, Sarah
Yussoff, Noor Haliza
author_facet Sarmidi, Sardiana
Abdul Wahab, Azantee Yazmie
Azizan, Azha Syahril
Mubarak, Sarah
Yussoff, Noor Haliza
author_sort Sarmidi, Sardiana
title Efficacy of antioxidant supplementation on sperm quality in men with oligoasthenoteratozoospermia
title_short Efficacy of antioxidant supplementation on sperm quality in men with oligoasthenoteratozoospermia
title_full Efficacy of antioxidant supplementation on sperm quality in men with oligoasthenoteratozoospermia
title_fullStr Efficacy of antioxidant supplementation on sperm quality in men with oligoasthenoteratozoospermia
title_full_unstemmed Efficacy of antioxidant supplementation on sperm quality in men with oligoasthenoteratozoospermia
title_sort efficacy of antioxidant supplementation on sperm quality in men with oligoasthenoteratozoospermia
publisher JRBF Online Publications
publishDate 2022
url http://irep.iium.edu.my/110290/1/110290_EFFICACY%20OF%20ANTIOXIDANT%20SUPPLEMENTATION%20ON%20SPERM%20QUALITY.pdf
http://irep.iium.edu.my/110290/
https://www.ivf-hub.net/journal-archive-new/2022-2/
_version_ 1789424070497927168
score 13.211869

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