Efficacy of antioxidant supplementation on sperm quality in men with oligoasthenoteratozoospermia
Introduction Evidence of a positive relationship between the intake of antioxidant supplements and the improvement of sperm parameters has been reported mainly in European and American populations and very little in Asian populations. Hence, we aimed to investigate the association between antioxid...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JRBF Online Publications
2022
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/110290/1/110290_EFFICACY%20OF%20ANTIOXIDANT%20SUPPLEMENTATION%20ON%20SPERM%20QUALITY.pdf http://irep.iium.edu.my/110290/ https://www.ivf-hub.net/journal-archive-new/2022-2/ |
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| Summary: | Introduction
Evidence of a positive relationship between the intake of antioxidant supplements and the improvement of
sperm parameters has been reported mainly in European and American populations and very little in Asian populations. Hence, we aimed to investigate the association between antioxidant supplement intake (i.e., Profertil®) and sperm parameters in Malaysian men with Oligoasthenoteratozoospermia
(OAT).
Materials and methods: This is a single-centre retrospective study that investigated a total of 195 men
with OAT whose female partners underwent ART treatment between 2016 and 2021. They were divided
into 2 groups; a treatment group where male patients received two daily capsules of the antioxidant
supplement (Profertil®) for 3 months (n = 92) and a control group where no micronutrient was given to the
male partner (n = 103). Sperm parameters, including semen volume, sperm concentration, progressive
motility, total motility, and morphology, were analyzed before and after treatment. A Kruskal-Wallis test
was performed to compare the median levels of the sperm parameters. A Chi-square test was performed
to compare the frequencies of normal morphology between the studied groups.
Results: Demographic and baseline characteristics showed no significant differences except for the
mean age of the husband and the etiology of infertility (p<0.05). When compared to their baseline sperm
quality, men receiving Profertil® had highly significant increases in median sperm concentration
(p<0.0001), motility (p<0.0001), progressive motility (p<0.0001), total sperm count (p<0.0001), total
sperm motility (p=0.01) and total progressive motility (p<0.0001). Moreover, sperm abnormality of a total
of 24 (26.1%) men improved after receiving Profertil® (p=0.013).
Conclusion: Our data showed that antioxidants (Profertil®) have a positive effect on semen parameters
in men with OAT |
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