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In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines

In searching for drugs from natural product scaffolds has gained interest among researchers. In this study, a series of twelve halogenated thiourea (ATX 1-12) via chemical modification of aspirin (a natural product derivative) and evaluated for cytotoxic activity against nasopharyngeal carcinoma...

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Main Authors: Norsyafikah Asyilla, Nordin, Vannessa, Lawai, Zainab, Ngaini, Ainaa Nadiah, Abd Halim
Format: Article
Language:English
Published: 2018
Subjects:
RS Pharmacy and materia medica
Online Access:http://eprints.unisza.edu.my/6141/1/FH02-FF-18-19751.pdf
http://eprints.unisza.edu.my/6141/
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spelling my-unisza-ir.61412022-03-13T04:00:10Z http://eprints.unisza.edu.my/6141/ In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines Norsyafikah Asyilla, Nordin Vannessa, Lawai Zainab, Ngaini Ainaa Nadiah, Abd Halim RS Pharmacy and materia medica In searching for drugs from natural product scaffolds has gained interest among researchers. In this study, a series of twelve halogenated thiourea (ATX 1-12) via chemical modification of aspirin (a natural product derivative) and evaluated for cytotoxic activity against nasopharyngeal carcinoma (NPC) cell lines, HK-1 via MTS-based colorimetric assay. The cytotoxicity studies demonstrated that halogens at meta position of ATX showed promising activity against HK-1 cells (IC50 value �15 mM) in comparison to cisplatin, a positive cytotoxic drug (IC50 value ¼8.9±1.9 mM). ATX 11, bearing iodine at meta position, showed robust cytotoxicity against HK-1 cells with an IC50 value of 4.7±0.7mM. Molecular docking interactions between ATX 11 and cyclooxygenase-2 demonstrated a robust binding affinity value of �8.1 kcal/mol as compared to aspirin’s binding affinity value of �6.4 kcal/mol. The findings represent a promising lead molecule from natural product with excellent cytotoxic activity against NPC cell lines. 2018-12 Article PeerReviewed text en http://eprints.unisza.edu.my/6141/1/FH02-FF-18-19751.pdf Norsyafikah Asyilla, Nordin and Vannessa, Lawai and Zainab, Ngaini and Ainaa Nadiah, Abd Halim (2018) In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines. Natural Product Research, 1 (1). pp. 1-10. ISSN 1478-6419
institution Universiti Sultan Zainal Abidin
building UNISZA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sultan Zainal Abidin
content_source UNISZA Institutional Repository
url_provider https://eprints.unisza.edu.my/
language English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Norsyafikah Asyilla, Nordin
Vannessa, Lawai
Zainab, Ngaini
Ainaa Nadiah, Abd Halim
In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines
description In searching for drugs from natural product scaffolds has gained interest among researchers. In this study, a series of twelve halogenated thiourea (ATX 1-12) via chemical modification of aspirin (a natural product derivative) and evaluated for cytotoxic activity against nasopharyngeal carcinoma (NPC) cell lines, HK-1 via MTS-based colorimetric assay. The cytotoxicity studies demonstrated that halogens at meta position of ATX showed promising activity against HK-1 cells (IC50 value �15 mM) in comparison to cisplatin, a positive cytotoxic drug (IC50 value ¼8.9±1.9 mM). ATX 11, bearing iodine at meta position, showed robust cytotoxicity against HK-1 cells with an IC50 value of 4.7±0.7mM. Molecular docking interactions between ATX 11 and cyclooxygenase-2 demonstrated a robust binding affinity value of �8.1 kcal/mol as compared to aspirin’s binding affinity value of �6.4 kcal/mol. The findings represent a promising lead molecule from natural product with excellent cytotoxic activity against NPC cell lines.
format Article
author Norsyafikah Asyilla, Nordin
Vannessa, Lawai
Zainab, Ngaini
Ainaa Nadiah, Abd Halim
author_facet Norsyafikah Asyilla, Nordin
Vannessa, Lawai
Zainab, Ngaini
Ainaa Nadiah, Abd Halim
author_sort Norsyafikah Asyilla, Nordin
title In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines
title_short In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines
title_full In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines
title_fullStr In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines
title_full_unstemmed In vitro cytotoxicity evaluation of thiourea derivatives bearing Salix sp. constituent against HK-1 cell lines
title_sort in vitro cytotoxicity evaluation of thiourea derivatives bearing salix sp. constituent against hk-1 cell lines
publishDate 2018
url http://eprints.unisza.edu.my/6141/1/FH02-FF-18-19751.pdf
http://eprints.unisza.edu.my/6141/
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score 13.211869

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